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Direct B-12

product on market Tablet or Pill Foster Regal Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

This formula contains B-complex vitamins and biotin, which are supported by strong evidence for supporting energy metabolism and neurological function. These ingredients play critical roles in red blood cell formation and cellular health. Research indicates a high safety profile for these nutrients when taken within recommended daily limits.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Direct B-12
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
90
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg (250% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)
1000 mcg (16666% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
25 mcg (8.3% DV)
Within RDA (0.8× RDA) 27 studies (A:0, B:11)

Other Ingredients

Mannitol natural Cherry flavor Vegetable Stearic Acid Vegetable Cellulose L-Ascorbic Acid Vegetable Magnesium Stearate Silica Stevia
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take 1 or 2 tablets daily. Allow tablet to dissolve under tongue.

Warnings & Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Formulation Notes

Gluten free

Vegetarian formula

Sublingual

With B-6, Folic acid & Biotin

Nutritionally supports healthy nervous system and cardiovascular function

Methylcobalamin is the form of B-12 active in the central nervous system. The liver may not convert cyanocobalamin, the common supplement form of vitamin B-12, into adequate amounts of methylcobalamin the body may need.

Mfg. in a Ko Kosher Certified, FDA Registered Facility using Good Manufacturing Practices (GMPs)

Mfg. in a Ko Kosher Certified, FDA Registered Facility using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight.

Made in USA

Additional Information

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

Metadata

Product Details

DSLD Entry Date2022-02-23
Product TypeVitamin
FormTablet or Pill
BrandFoster Regal
DSLD ID260026
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.