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St. John's Wort 450 mg

product on market Tablet or Pill Nature's Way Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for St. John's Wort 450 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
Market median: 300.0mg (240 products) 20 studies — no high-quality reviews

Other Ingredients

Cellulose Sodium Croscarmellose Stearic Acid Magnesium Stearate Silica Hypromellose Glycerin Carnauba wax
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendation: Take 1 tablet twice daily.

Warnings & Precautions

Warning: This product should not be used by pregnant or nursing women, or by individuals who are taking antidepressant medications. Individuals taking other medications should seek the advice of a prescribing physician prior to using this product.

Avoid excessive exposure to UV radiation (e.g., sunlight or tanning) while using the product.

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Formulation Notes

Promotes a positive mood St. John's Wort has been used for centuries to help promote a positive mood.

We source from the regions where it grows best, like Chile and Europe, where the soil is dry and the cooler climate makes for perfect growing conditions. At Nature's Way, we believe nature knows best. That's why our mission is to seek out the best herbs the earth has to give. It's the way we deliver uncompromising quality and help you live healthier.

Premium extract

Gluten free. No sugar, salt, yeast, wheat, soy, dairy products, or artificial colors, flavors, or preservatives.

Vegan

St. John's Wort 450 mg per serving

Additional Information

Bottles made from 97% post-consumer recycled plastic

Quality Global Sourcing - Bottled & Tested in the USA

Metadata

Product Details

UPC / SKU7 63948 08676 4
DSLD Entry Date2022-01-22
Product TypeBotanical
FormTablet or Pill
DSLD ID259591
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.