SAMe

product on market Capsule Metabolic Maintenance Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

SAMe is supported by moderate evidence for mood and joint health, while calcium and magnesium are well-established for bone and neuromuscular function. Research indicates these ingredients generally support metabolic and skeletal health. The overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calcium
75 mg (8% DV)
75 mg (19% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
200 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

vegetarian capsule L-Leucine
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

DIRECTIONS: One to two (1-2) capsules daily as a dietary supplement, or as directed by a Doctor. Best taken between meals.

Warnings & Precautions

KEEP OUT OF THE REACH OF CHILDREN.

CAUTION: Pregnant or lactating women, consult your healthcare professional before taking this product.

If you suffer from bipolar (manic) depression, do not use this product.

Formulation Notes

Excipient-free.

Additional Information

STORAGE: Keep tightly closed; refrigerate immediately. Guaranteed potency for 6 months from date of manufacture if refrigerated. Imprint is "date of manufacture," not expiration date.

Manufactured in a GMP Certified Facility

11354A MFG 1/11

V-09

Each preservative-free vegetarian capsule contains only the active ingredients listed on the label.

Metadata

Product Details

UPC / SKU8 38287 00154 6
DSLD Entry Date2013-08-23
Product TypeOther Combinations
FormCapsule
DSLD ID25120
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.