Home/ Supplements/ St Johns Wort/ St. John's Wort

St. John's Wort

product on market Capsule Karuna Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for St. John's Wort
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews

Other Ingredients

Vegetable Capsule Rice Flour Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested use for adults: One capsule 2-3 times daily or as directed by your health care practitioner.

Warnings & Precautions

Warning: If you are pregnant, trying to become pregnant, nursing, or taking any drugs or medications consult your physician before taking. St. John's Wort may cause undesirable reactions when combined with certain drugs or prescription medications.

Notice: Avoid excessive exposure to UV irradiation (e.g., sunlight; tanning) when using this product.

Formulation Notes

This product contains no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring.

Additional Information

6204-LB4

KARUNA(R) RESPONSIBLE NUTRITION(TM)

Standardized Extract

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Keep in a cool, dry place, tightly capped.

Metadata

Product Details

DSLD Entry Date2013-08-23
Product TypeBotanical
FormCapsule
BrandKaruna
DSLD ID25105
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
Compare

Similar Products

Mood Aid With 5-HTP & St. John's Wort
Nature's Way · Capsule
100
St. John's Wort Plus 300 mg Standardized Extract w...
Martin Avenue Pharmacy · Capsule
100
Mood Health Support With St. John's Wort & Kava
Martin Avenue Pharmacy · Capsule
100
St. John's Wort
DC · Capsule
100
St. John's Wort
Wonder Laboratories · Capsule
100
View all St Johns Wort products →
St Johns Wort research Best St Johns Wort All St Johns Wort products More from Karuna View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.