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Homocysteine Cardioplex

product on market Capsule Patient One 1 MediNutritionals Safety: 94/100
94/100

This product looks safe

  • Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B-6, folate, and B12 have strong evidence for lowering homocysteine levels, while N-acetyl-L-cysteine and magnesium provide additional metabolic support. Research indicates these nutrients are generally effective for cardiovascular health maintenance. The overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Homocysteine Cardioplex
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg (5882% DV)
76.9× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1333 mcg DFE (333% DV)
Exceeds UL by 1333.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
500 mcg (20833% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
150 mg (38% DV)
Within RDA (0.4× RDA) 316 studies (A:8, B:159)
N-Acetyl-L-Cysteine
600 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Vegetable Cellulose Leucine Rice Flour
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Take 3 capsules daily, in divided doses with meals, as a dietary supplement or as directed by your health practitioner.

Warnings & Precautions

Caution: If you are pregnant, nursing, or taking any medications, consult your health practitioner before use.

Discontinue use and consult your health practitioner if any adverse reactions occur.

Keep out of reach out of children.

Use only if safety seal is intact.

Formulation Notes

Vegetarian

Gluten free Non-GMO Free Of: Milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast and gluten. Free of ingredients derived from GMOs.

With NAC & Quatrefolic 5-MTHF

Additional Information

Store in a cool, dry place.

BPA free

Exclusive Professional Formulas

Metadata

Product Details

UPC / SKU8 53959 00413 7
DSLD Entry Date2021-05-22
Product TypeOther Combinations
FormCapsule
BrandPatient One 1 MediNutritionals
DSLD ID249304
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.