Home/ Supplements/ Niacin/ Flush-Free Niacin 250 mg

Flush-Free Niacin 250 mg

product on market Capsule Douglas Cooper Co. Safety: 80/100
80/100

This product is generally safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin and inositol are utilized to support lipid metabolism and cellular signaling, with moderate evidence supporting their role in cardiovascular health. The combination of inositol with niacin is specifically designed to reduce the occurrence of cutaneous flushing. Research indicates these ingredients are generally well-tolerated at this dosage.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Flush-Free Niacin 250 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Vcap(s)
Serving Size
45
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (2500% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)
135 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Rice Flour Cellulose Cellulose Stearic Acid Guar Gum Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: As a dietary supplement, take 2 Vcaps daily as needed, preferably with meals; or take as directed by your health practitioner.

Warnings & Precautions

Caution: Not to be used by pregnant/lactating women or those with liver problems, stomach ulcers or diabetes unless recommended by your healthcare practitioner.

To report a serious adverse event, or for product information, contact 1-800-234-8686

Formulation Notes

Niacin (Vitamin B-3) is an essential B-vitamin necessary for good health. Many Niacin supplements cause a temporary Niacin flush or tingling red rash on the skin when taken in large doses. This flush-free Niacin is formulated to avoid such reactions.

Inositol Hexanicotinate is a stable, on-flushing source of Niacin. This superior source of Niacin works to reduce the common "niacin-flush" problems associated with high doses of Niacin supplements.

Contains no sugar, salt, yeast, wheat, gluten, corn, soy, milk, egg or preservatives.

Vegetarian formula.

Additional Information

Douglas Cooper Co. "Trace Minerals Make the Difference" Since 1950

Metadata

Product Details

DSLD Entry Date2021-05-22
Product TypeOther Combinations
FormCapsule
DSLD ID247346
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.