🟢 90/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • 75% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label Data

1 Caplet(s) Serving Size
30 Servings
Botanical with Nutrients Product Type
75% Evidence Coverage

Supplement Facts — Evidence Check

15 mg (100% DV)
✅ Within RDA (1.0× RDA of 15 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 15mg UL 1000mg
50 mg (313% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 50mg UL 35mg
10 mg (91% DV)
✅ Within RDA (0.9× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 10mg UL 40mg
Chasteberry & Nutrient Blend

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Hydroxypropyl Cellulose Stearic Acid Vegetable Juice Magnesium Stearate Coating Natural flavor

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (81% of products) Nutrient (56% of products) Qualified Health (2% of products)

Target Groups

Vegan Vegetarian Women (not pregnant or lactating) Adult Female (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions for use and storage: Take (1) caplet daily at any time of the day with food. When taken daily, results seen in as little as one cycle. For best results, a minimum of 90 days is important.

⚠️ Warnings & Precautions

Caution: As with any dietary supplement, please inform your healthcare professional before taking.

Do not take if pregnant, breastfeeding or intending to become pregnant.

Keep out of reach of children.

Tamper evident: Do not use this product if safety seal bearing "sealed for your protection" under cap is missing.

For questions, concerns or to report an adverse event, please call 1-800-722-3476

🧪 Formulation Notes

AZO Cycle Care & Comfort is a proactive approach to hormonal health. When taken daily, AZO Cycle Care & Comfort formula works naturally with your body to help deal with those hormonal fluctuations, so you can feel your best, more days of the month.

Be on your way to a better cycle with a drug-free foundation to support hormonal health and help manage the symptoms brought on by your monthly cycle.

AZO Cycle Care & Comfort is specially formulated with a Chasteberry & Nutrient Blend plus skin-loving nutrients.

When taken daily, AZO Cycle Care & Comfort will help relieve: Bloating & Cramping Breast Tenderness Irritability Plus, supports a regular & consistent cycle and clear, healthy skin.

Chastetree Berry This naturally sourced plant from the Mediterranean has been used by women for thousands of years to support hormonal health. Skin nutrients to minimize cycle-related breakouts and help keep skin glowing and fresh, no matter what time of the month.

Gluten Free Non-GMO Drug Free Dairy Free No Artificial Dyes

Doctor Formulated

Vegan

A Daily Approach to Help Relieve: Irritability, Boating & Cramping Plus Supports Clear, Healthy Skin

Chasteberry Blend + Skin Nutrients

Made in USA with US and imported materials.

Slight variations in bilayer caplet color may occur due to the naturally sourced colorants.

Additional Information

The proactive way to address those uncomfortable symptoms that occur before and during your period, that can leave you feeling less than your best.

Your hormones naturally fluctuate all through the month, not just during your period. These ebbs and flows can contribute to both physical and emotional symptoms occurring for up to 3/4 of your cycle!

Let's be honest, who wants to feel less than their best for that long each month? Your monthly cycle Pre-Menstrual Period Best Days

Own your own cycle with AZO

Store at room temperature. Do not expose to excessive heat, humidity or direct sunlight.

From the no. 1 Most Trusted Brand AZO visit us online at: www.azoproducts.com #1 Most Trusted Brand based on Total AZO Brand Nielsen data through 3/14/20 and the 2019 Pharmacy Times Survey (Urinary Pain Relief and Cranberry Supplement categories).

Product Details

UPC / SKU 7 8765176020 9
DSLD Entry Date 2021-03-25
Product Type Botanical with Nutrients
Form Other (e.g. tea bag)
Brand AZO
DSLD ID 243439
Data Updated 2026-04-11

Research Evidence

253 Research Sources
55 Avg Quality Score
128 Meta Analysis
52 Systematic Review
41 Rct
24 Clinical Trial
3 Regulatory Source
1 Narrative Review
1 Other
1 Guideline
1 Openfda Safety
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Systematic Review The Cochrane database of systematic reviews 2017
A Vitamin E for Alzheimer's disease and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2008
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2012
A Exercise for intermittent claudication
Meta Analysis The Cochrane database of systematic reviews 2017
A Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2021
A Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis
Meta Analysis European journal of clinical nutrition 2023
A Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Rct JAMA 2011
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2017
B Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.
Guideline JAMA 2022
View all evidence for Vitamin E →

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