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5-MTHF 7.5 mg

product on market Capsule Fresh Nutrition Safety: 60/100
60/100

Review before taking

  • 5-MTHF: 7.5mg is 7.5× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-MTHF provides a bioactive form of folate used to support methylation processes and homocysteine levels, with moderate research evidence for specific deficiencies. However, the safety score of 60 indicates potential concerns regarding high-dose supplementation. Users should be aware of possible adverse effects associated with this concentration.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

5-MTHF: 7.5mg is 7.5× the Tolerable Upper Intake Level (1.0mg)

AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 7.5mg of 5-MTHF, which is 7.5 times higher than the recommended tolerable upper intake level of 1.0mg.

Label

Product Label

Label for 5-MTHF 7.5 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

7.5 mg
Exceeds UL by 7.5× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

non-GMO Rice Flour powder Microcrystalline Cellulose
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommended Dosage Take one (1) capsule daily with sufficient water before a meal.

Formulation Notes

Vegan

Non GMO Gluten free Soy free

5-MTHF Folate is an essential micronutrient needed for optimal methylation. 5-MTHF is the bioavailable form of folate and it significantly impacts biochemical reactions in the body. When optimal methylation occurs, the body is better able to regulate cardiovascular, neurological, reproductive, and detoxification systems.

No artificial colors. No artificial flavors. No preservatives. Made with Non-GMO, all natural ingredients!

Made with Non-GMO, all natural ingredients!

Maximum potency

Methylfolate 7.5 mg per serving

Brain health support Promotes positive mood & cognition Supports cardiovascular health Superior bioavailability

Fresh Nutrition produces the most potent and highest quality 5-MTHF. Our raw materials are carefully sourced and cultivated; contain no fillers, additives, and are manufactured domestically in a cGMP facility. Thank you for choosing Fresh!

Additional Information

Fresh Nutrition Our goal is to create high-quality natural products using both organic and responsibly sourced ingredients to optimize health and well-being.

Quality Verified Third Party Tested For Quality And Purity To provide our consumers with complete confidence in our product quality, every batch is 3rd party tested for quality & purity.

Made in USA

Metadata

Product Details

UPC / SKU8 50012 95658 7
DSLD Entry Date2021-03-25
Product TypeVitamin
FormCapsule
DSLD ID242043
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.