🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
120 Servings
Amino acid/Protein Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Guar Gum Hydroxypropyl Cellulose Magnesium Stearate Croscarmellose Sodium Xanthan Gum Clear Coating Silicon Dioxide Micro Wax

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Use: Take 1 tablet daily, with or without food. Or use as directed by your healthcare professional.

⚠️ Warnings & Precautions

Should not be used if tamper evident seal is broken.

Keep out of reach of children.

🧪 Formulation Notes

5-HTP is the raw material your body uses to make serotonin, the master mood-regulating neurotransmitter. Increasing the amount of 5-HTP in your body supports serotonin production. Because 5-HTP has a very short half-life in the body, we employ our patented Sustained Release Technology (SRT), so that you can get a longer-lasting effect. And to ensure you get the highest quality of 5-HTP available, we use only the all-natural form from the seeds of the Griffonia simplicifolia tree found primarily in the West African countries.

5-Hydroxytryptophan

Maintains mental and emotional well-being. 8 hours

100% non-GMO ingredients GF Gluten free

Vegan

Product of the U.S.A. with select ingredients thoughtfully curated from around the world.

Additional Information

Store in a cool dry place.

Jigsaw Health It's fun to feel good

Product Details

UPC / SKU 8 76634 00017 0
DSLD Entry Date 2021-01-22
Product Type Amino acid/Protein
Form Tablet or Pill
DSLD ID 240597
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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