Home/ Supplements/ Folate/ L-Methylfolate 2.5 mg

L-Methylfolate 2.5 mg

product on market Capsule Metabolic Maintenance Safety: 80/100
80/100

This product is generally safe

  • Folate: 4.2mg is 4.2× the Tolerable Upper Intake Level (1.0mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

L-methylfolate is a bioactive form of folate used to support methylation and neurotransmitter synthesis, backed by moderate evidence for specific deficiencies. Glycine serves as a precursor for glutathione and supports protein synthesis. Due to the very low evidence coverage for this specific formulation, the overall clinical data is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 4.2mg is 4.2× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for L-Methylfolate 2.5 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

4.2 mg DFE (1050% DV)
Exceeds UL by 4.2× (UL: 1.0 mg) 226 studies (A:10, B:105)
Glycine
270 mg

Other Ingredients

Vegetarian Cellulose Capsule
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions: Use only as directed by a healthcare professional.

Warnings & Precautions

Caution: Pregnant or lactating women, or individuals taking prescription medications, consult your healthcare professional before taking this product.

Keep tightly closed in a cool, dry place, out of the reach of children.

Formulation Notes

Gluten and excipient-free

Manufactured in a GMP Compliant Facility

Additional Information

Keep tightly closed in a cool, dry place, out of the reach of children.

Metadata

Product Details

UPC / SKU8 38287 00532 2
DSLD Entry Date2020-11-21
Product TypeOther Combinations
FormCapsule
DSLD ID240238
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.