🟡 60/100

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  • Nicotinamide Riboside Chloride: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

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Safety Alerts

⚠️ Nicotinamide Riboside Chloride: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)

The safety score is low because the amount of Nicotinamide Riboside Chloride in this product significantly exceeds the recommended maximum daily intake level.

Label Data

2 Capsule(s) Serving Size
30 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

⚠️ Exceeds Tolerable Upper Intake Level by 7.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 250mg UL 35mg

Other Ingredients

Rice Bran Magnesium Stearate

Label Claims — Verification

All Other
All Other (100% of products) Structure/Function (90% of products) Nutrient (28% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Recommended use: Adults. Take 2 capsule a day.

⚠️ Warnings & Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of childrens' reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

🧪 Formulation Notes

Each capsule contains 125 mg of nicotinamide riboside chloride.

Additional Information

Store away from direct light, heat and humidity.

Product Details

DSLD Entry Date 2020-06-24
Product Type Vitamin
Form Capsule
Brand SuperSmart
DSLD ID 222934
Data Updated 2026-04-11

Research Evidence

10 Research Sources
49 Avg Quality Score
8 Rct
1 Systematic Review
1 Clinical Trial
B Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Rct Nature communications 2018
C The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials
Systematic Review Frontiers in nutrition 2023
C Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial.
Rct Nature aging
C Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
Rct Scientific reports 2019
C Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Rct Cell reports 2019
C Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Rct Aging cell 2023
C Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
Rct BMC nephrology 2020
C Clinical Trial of Niagen to Examine Recovery in People With Persistent Cognitive and Physical Symptoms After COVID-19
Clinical Trial ClinicalTrials.gov 2021
C A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.
Rct JCI insight
C Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.
Rct Aging cell
View all evidence for Nicotinamide Riboside →

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