🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 80% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

3 Capsule(s) Serving Size
30 Servings
Botanical Product Type
80% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)
This product: 600mg
📊 Market median: 400.0mg (142 products) 📚 10 studies (Tier A: 0, B: 2)
This product: 400mg
Bacopa extract
300 mg
📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)
This product: 500mg
📊 Market median: 450.0mg (502 products) 📚 28 studies (Tier A: 0, B: 8)
This product: 250mg

Other Ingredients

Vegetarian Capsule Microcrystalline Cellulose Magnesium Stearate Silica

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (84% of products) Nutrient (3% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested usage: 3 capsules per day or as directed by a health professional.

⚠️ Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

🧪 Formulation Notes

Three Brains is a line of supplements designed to support the critical relationship between our head, heart, and gut. Together, these three "brains" influence our cognition and support a healthy mind. Brain Defense supports memory, cognition, brain function, and cardiovascular health by supporting healthy cortisol and C-reactive protein levels already within the normal range. These are the biomarkers of physical stress and signs of everyday stress such as fatigue, occasional sleeplessness, irritability, mild memory loss, and temporary difficulties concentrating. It also supports an acute inflammatory response for a healthy head, heart, and gut. Manufactured by natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Supports memory and overall brain function through healthy inflammatory responses

Additional Information

isura Non-GMO - Mass Spec Documentation Lab tested

For freshness, store in a cool, dry place.

Recyclable container and label. Product of Canada

Purity & Potency Guaranteed

Product Details

UPC / SKU 0 68958 03060 9
DSLD Entry Date 2020-05-22
Product Type Botanical
Form Capsule
DSLD ID 220815
Data Updated 2026-04-11

Research Evidence

33 Research Sources
55 Avg Quality Score
17 Systematic Review
12 Meta Analysis
3 Rct
1 Clinical Trial
A Oral herbal therapies for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2014
B Interventions for treating collagenous colitis
Meta Analysis The Cochrane database of systematic reviews 2017
B Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis
Meta Analysis Seminars in arthritis and rheumatism 2018
B Evaluating the efficacy and safety of Curcuma longa, Boswellia serrata, and their mixed formulation in treating knee osteoarthritis: A systematic review and network meta-analysis
Systematic Review Complementary therapies in medicine 2026
B Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis
Meta Analysis BMC complementary medicine and therapies 2020
B Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis
Systematic Review Frontiers in pharmacology 2022
B Interventions for treating collagenous colitis
Meta Analysis The Cochrane database of systematic reviews 2008
B Ayurvedic interventions for osteoarthritis: a systematic review and meta-analysis
Meta Analysis Rheumatology international 2015
B Oral herbal medicines marketed in Brazil for the treatment of osteoarthritis: A systematic review and meta-analysis
Meta Analysis Phytotherapy research : PTR 2017
B Frankincense: systematic review
Systematic Review BMJ (Clinical research ed.) 2008
View all evidence for Boswellia →

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