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Homocysteine Modulators

product on market Capsule Solgar Safety: 94/100
94/100

This product looks safe

  • Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines B vitamins and trimethylglycine, which are supported by strong evidence for their role in lowering homocysteine levels. These ingredients act as methyl donors to facilitate the conversion of homocysteine to methionine. Research indicates these nutrients are generally safe and effective for supporting cardiovascular and neurological health.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Homocysteine Modulators
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Vegetarian Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
50 mg (2941% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
666 mcg DFE (167% DV)
Exceeds UL by 666.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
500 mcg (20833% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
4.6× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)

Other Ingredients

Vegetable Cellulose Stearic Acid Microcrystalline Cellulose Vegetable Magnesium Stearate PhytO2X Antioxidant Blend
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement for adults, take two (2) vegetable capsules daily, preferably with a meal, or as directed by a healthcare practitioner.

Warnings & Precautions

If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Formulation Notes

Free of: Gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavor and color.

Solgar’s KOF-K certification #K-1250

Suitable for vegans

Gluten, wheat & dairy free Non-GMO

Additional Information

Solgar since 1947

Gold Specifics

GF Certified Gluten-free K Parve (Kosher)

Store at room temperature.

Metadata

Product Details

UPC / SKU0 33984 01411 4
DSLD Entry Date2020-04-23
Product TypeOther Combinations
FormCapsule
BrandSolgar
DSLD ID218309
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.