🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

Product Label

📸

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Label Data

5 Drop(s) Serving Size
30 Servings
Other Combinations Product Type
25% Evidence Coverage

Supplement Facts — Evidence Check

Calories
Total Carbohydrates
📊 Market median: 400.0mg (142 products) 📚 10 studies (Tier A: 0, B: 2)
This product: 1mg

Other Ingredients

Rice Bran Oil Carnauba Wax Sucrose Maltodextrin Sodium Ascorbate

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (91% of products) Nutrient (14% of products)

Target Groups

Infants/Baby (0 - 1 Year) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions for 0-12 Months: Use 5 drops once a day. Dispense directly into baby's mouth, bottle or while breastfeeding. Shake well before use. Before first use, replace cap with dropper and discard original cap. Washing of dropper in between use is not recommended. Once opened, use within 60 days.

⚠️ Warnings & Precautions

Warning: Keep out of reach of children.

Inform a healthcare professional before starting any dietary supplement, particularly if there is a known immune-compromised condition.

If your infant develops an allergic reaction such as a rash, itching, wheezing or hives, discontinue use and call your doctor. When first taking a probiotic, your baby's gut microbiom adjusts. Your baby may experience minor bloating, gas or intestinal gurgling which should subside with continued use. Consult your healthcare professional if symptoms continue after two weeks.

For questions, concerns or to report an adverse event, please call (800) 722-3476.

Tamper Evident: Do not use if bottle or dropper appears to be opened.

While there are no dairy-derived ingredients in this product, it is produced in a facility that also handles dairy ingredients.

🧪 Formulation Notes

Contains none of the following: artificial dyes, preservatives, dairy, sugar, lactose, milk, yeast, soy or gluten.

Meets the FDA's guidelines for gluten-free.

Contains sucrose which adds a dietarily insignificant amount of sugar. Not a reduced calorie food.

Helps reduce fussiness & crying Due to occasional digestive upset.

Probiotic + chamomile drops

Helps reduce occasional digestive upset

0-12 months

With chamomile extract

Culturelle Baby Calm + Comfort helps you soothe your baby.

Culturelle Baby Calm + Comfort contains safe and gentle ingredients that work naturally with your baby's body to help reduce fussiness and crying. Probiotic The most clinically studied probiotic in infants, lacobacillus rhamnosus GG, restores the natural balance of good bacteria in their digestive tract to help reduce occasional digestive upset. Based on the number of lactobacillus rhamnosus GG studies, as of January 2018. + Chamomile With chamomile extract

Additional Information

Storage Instructions: Store Culturelle in a cool, dry place away from direct sunlight. Guaranteed potency through date on box when stored as directed.

For children over 1 year: Take Culturelle Baby Grow + Thrive Packets as directed on the package.

#1 Pediatrician recommended brand Based on a 2018 survey among pediatricians recommending a probiotic brand.

Product Details

UPC / SKU 0 49100 40075 4
DSLD Entry Date 2020-04-23
Product Type Other Combinations
Form Liquid
DSLD ID 218199
Data Updated 2026-04-11

Research Evidence

691 Research Sources
52 Avg Quality Score
255 Clinical Trial
205 Meta Analysis
123 Rct
81 Systematic Review
18 Cochrane Review
2 Guideline
2 Regulatory Source
1 Other
1 Narrative Review
1 Openfda Safety
A Probiotics for preventing acute upper respiratory tract infections
Systematic Review The Cochrane database of systematic reviews 2022
A Probiotics for preventing acute upper respiratory tract infections
Meta Analysis The Cochrane database of systematic reviews 2015
A Probiotics for maintenance of remission in ulcerative colitis
Meta Analysis The Cochrane database of systematic reviews 2020
A Probiotics for induction of remission in ulcerative colitis
Meta Analysis The Cochrane database of systematic reviews 2020
A Probiotics for preventing acute upper respiratory tract infections
Meta Analysis The Cochrane database of systematic reviews 2011
A Probiotics for treating eczema
Meta Analysis The Cochrane database of systematic reviews 2018
A Probiotics for treating acute infectious diarrhoea
Meta Analysis The Cochrane database of systematic reviews 2020
A The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies
Systematic Review International journal of molecular sciences 2022
A Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Meta Analysis The Cochrane database of systematic reviews 2017
A Probiotics to prevent infantile colic
Meta Analysis The Cochrane database of systematic reviews 2019
View all evidence for Probiotics →

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