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Niacin 500 Vitamin B3 500 mg

product on market Capsule Dr. Clark Store Safety: 60/100
60/100

Review before taking

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is used to support cholesterol management and cellular energy production, with strong evidence supporting its role in lipid metabolism. However, the safety score indicates potential concerns, as high doses can cause flushing or liver stress. Evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of Niacin is over 14 times higher than the recommended upper limit for daily intake.

Label

Product Label

Label for Niacin 500 Vitamin B3 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
100
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (2500% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)

Other Ingredients

Gelatin Capsules
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults take 1 capsule daily, preferably with a meal, or as directed by a person healthcare professional. Consult with a physician before administering to children.

Warnings & Precautions

Consult with a physician before administering to children.

Note: Niacin may cause temporary skin flushing, tingling, or itching, especially when taken on an empty stomach. This is a harmless reaction and will pass.

Keep away from children.

Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.

If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.

Formulation Notes

Our products don't contain flow agents like Magnesium Stearate. Not now, not ever.

Promotes energy metabolism

Additional Information

Made in USA

Leader in purity Established by Dr. Clark's Family in 1993

Store at room temperature.

Company does not adopt any Dr. Clark claims.

Metadata

Product Details

UPC / SKU6 52384 10545 3
DSLD Entry Date2020-03-24
Product TypeVitamin
FormCapsule
BrandDr. Clark Store
DSLD ID215808
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.