R-Lipoic Acid

product on market Capsule AOR Advanced Orthomolecular Research Premium Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

R-alpha lipoic acid and biotin are supported by moderate to strong evidence for supporting metabolic function and glucose regulation. Sodium is a basic electrolyte used for stabilization in this formulation. Overall, the evidence coverage for this specific ingredient combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for R-Lipoic Acid
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Other Combinations
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

300 mcg (1000% DV)
10.0× RDA — above typical dose 27 studies (A:0, B:11)
Sodium
45 mg (2% DV)
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews

Other Ingredients

organic Rice Dicalcium Phosphate Capsule
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 capsule 1-3 times daily with/without food, or as directed by a qualified health care practitioner.

Warnings & Precautions

Do not use if safety seal is broken

Warning: Consult your physician if you are pregnant, lactating, if you have a medical condition, or if you’re taking any medication.

Keep out of reach of children.

Caution: If you experience sweating, paleness, chills, headaches, dizziness and/or confusion, discontinue use and consult a health care practitioner as these may be symptoms of serious low blood sugar.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Formulation Notes

GMP Manufacturing Quality assured Independent testing

Discussion: AOR’s R-Lipoic Acid has the natural ‘R’ form of this vital nutrient produced in the body, unlike other supplements which also contain equal amounts of the synthetic, inactive ‘S’ form. The natural ‘R’ form is more potent than the S-form, and that in some cases the S-form interferes with R-lipoic acids actions in the body.

Supports normal energy production

Vegan

Non-GMO Gluten free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, corn, nuts, peanuts, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Additional Information

Store tightly sealed in a cool, dry place

Delayed Release

Product of USA

Metadata

Product Details

UPC / SKU6 24917 08005 6
DSLD Entry Date2020-03-24
Product TypeOther Combinations
FormCapsule
DSLD ID214876
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
52
Avg Quality
13
Rct
4
Meta Analysis
2
Systematic Review
2
Clinical Trial
A Alpha-lipoic acid for diabetic peripheral neuropathy
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy
Rct Nutrients 2024 PubMed DOI
B Alpha Lipoic Acid Supplementation and Iron Homeostasis: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2024 PubMed DOI
B Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
Meta Analysis Medicine 2023 PubMed DOI
C The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Metabolism: clinical and experimental 2018 PubMed DOI
C A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy
Meta Analysis European journal of endocrinology 2012 PubMed DOI
C Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study
Rct Endocrine, metabolic & immune disorders drug targets 2020 PubMed DOI
C A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin
Rct Journal of postgraduate medicine 2024 PubMed DOI
C Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis
Systematic Review Canadian journal of diabetes 2024 PubMed DOI
C Effect analysis of tanshinone IIA sulfonate sodium combined with a-lipoic acid in patients with diabetes peripheral neuropathy.
Rct Pakistan journal of pharmaceutical sciences PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.