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MaxMethyl

product on market Capsule AOR Advanced Orthomolecular Research Advanced Safety: 90/100
90/100

This product looks safe

  • Folate: 1335mg is 1335.0× the Tolerable Upper Intake Level (1.0mg)
  • 75% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines B-vitamins and trimethylglycine to support methylation processes and homocysteine regulation. There is strong evidence for the role of folate and B12 in cardiovascular and neurological health. However, overall evidence coverage for this specific ingredient combination remains limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1335mg is 1335.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for MaxMethyl
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

51 mg (3000% DV)
39.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1335 mcg DFE (334% DV)
Exceeds UL by 1335.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
648 mcg (27000% DV)
270.0× RDA — above typical dose 139 studies (A:1, B:44)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Capsule Sodium Stearyl Fumarate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 capsule three times per day with or without food, or as directed by a qualified health care practitioner.

Warnings & Precautions

Do not use if safety seal is broken

Warning: Consult your physician before use if you are pregnant, lactating, have medical condition, or if you’re taking any medication.

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Formulation Notes

GMP Manufacturing Quality assured Independent testing

Discussion: MaxMethyl has nutrients that support the body’s healthy methylation, an important process for overall health. MaxMethyl also promotes healthy homocysteine metabolism.

Methylating agents and co-factors

Vegan

Non-GMO Gluten free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, corn, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Additional Information

Product of Canada

Store tightly sealed in a cool, dry place

Metadata

Product Details

UPC / SKU6 24917 08260 9
DSLD Entry Date2020-03-24
Product TypeOther Combinations
FormCapsule
BrandAOR Advanced Orthomolecular Research Advanced
DSLD ID214693
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.