Niacin 500 mg by Sundown — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label Data

1 Caplet(s) Serving Size

Single Vitamin and Mineral Product Type

50% Evidence Coverage

Supplement Facts — Evidence Check

Niacin

500 mg (3125% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 500mg UL 35mg

Calcium

106 mg (8% DV)

Other Ingredients

Vegetable Cellulose Stearic Acid Vegetable Magnesium Stearate

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: For adults, take one (1) caplet daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers.

⚠️ Warnings & Precautions

Keep out of reach of children.

Tamper Resistant: Do not use if seal under cap is broken or missing.

Warning: Not intended for use by pregnant or nursing women. If you are taking any meditations or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Notice: Use of this product may cause a temporary skin flushing (hot feeling and skin redness), burning, itching, or rash caused by an increase in blood flow near the skin. Sensitive individuals may experience unexpected drop of blood pressure or dizziness. Do not take on an empty stomach. Do not take more than the recommended dose unless prescribed by your doctor.

🧪 Formulation Notes

Clean Nutrition Sundown believes in clean nutrition and being transparent. That's why you won't find genetically modified ingredients, gluten, wheat, dairy, lactose or artificial flavors in any of our products. Non-GMO No gluten No wheat No milk No lactose No artificial color No artificial flavor No artificial sweetener No preservatives No sugar No soy No starch No yeast No peanuts No tree nuts No fish Sodium free

B Vitamins aid in the conversion of food into energy

Supports heart health & energy production

Vegetarian

Additional Information

Store at room temperature and avoid excessive heat.

Questions? Call toll free 1-888-VITAHELP (848-2435) or visit us at www.sundownnutrition.com Made in the USA with select ingredients from around the world US Only Discard seal & empty before recycling Check locally Plastic bottle how2recycle.info Not recycled in all communities

Product Details

UPC / SKU 0 30768 29505 9

DSLD Entry Date 2019-12-22

Product Type Single Vitamin and Mineral

Form Other (e.g. tea bag)

Brand Sundown

DSLD ID 212387

Data Updated 2026-04-11

Research Evidence

241 Research Sources

55 Avg Quality Score

113 Meta Analysis

75 Systematic Review

32 Rct

11 Clinical Trial

3 Other

3 Regulatory Source

1 Cochrane Review

1 Narrative Review

1 Openfda Safety

A Niacin for primary and secondary prevention of cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases

Meta Analysis BMJ (Clinical research ed.) 2013

PubMed DOI

A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients

Meta Analysis BMJ (Clinical research ed.) 2014

PubMed DOI

A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

Meta Analysis Nature medicine 2024

PubMed DOI

A Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Meta Analysis Nature genetics 2010

PubMed DOI

A Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Meta Analysis Nature genetics 2010

PubMed DOI

A Antidepressants for smoking cessation

Meta Analysis The Cochrane database of systematic reviews 2014

PubMed DOI

A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI Cochrane

B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis

Meta Analysis JAMA network open 2019

PubMed DOI

B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

Meta Analysis JAMA 2016

PubMed DOI

View all evidence for Niacin →