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Optimal Liposomal Active B12 with L-5-MTHF

product on market Liquid Seeking Health Safety: 87/100
87/100

This product is generally safe

  • Folate: 100mg is 100.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin B12 and folate are supported by strong evidence for maintaining neurological function and supporting red blood cell formation. The inclusion of a phospholipid complex aims to enhance nutrient absorption via liposomal delivery, though evidence for this specific delivery method is more limited. The profile is generally considered safe for most users.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 100mg is 100.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Optimal Liposomal Active B12 with L-5-MTHF
Open Full PDF View on NIH DSLD →
Details

Label Data

2 mL
Serving Size
30
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5000 mcg (208333% DV)
2083.3× RDA — above typical dose 139 studies (A:1, B:44)
100 mcg DFE (25% DV)
Exceeds UL by 100.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
Within RDA (0.4× RDA) 38 studies (A:1, B:7)

Other Ingredients

purified Water Glycerin Natural Flavors Potassium Sorbate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Suggested Use: Gently shake before use. Place 2 mL (1/2 tsp or about 40 drops) into a glass of juice or water and take by mouth. May also place directly into the mouth and swallow. Use as directed by your healthcare professional.

Warnings & Precautions

When taking this high level of Vitamin B12, track blood levels.

Children and pregnant or lactating women should consult with their healthcare professional prior to use.

Children and pregnant or lactating women should consult with their healthcare professional prior to use.

Keep out of reach of children.

Formulation Notes

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, or wheat.

Additional Information

Storage: Store in a cool, dry place away from direct sunlight. For maximum potency, after opening: refrigerate and use within 40 days.

Optimal Liposomal Active B12 Meets or Exceeds cGMP Standards. Find other effective health products at www.seekinghealth.com Physician Formulated

Metadata

Product Details

UPC / SKU7 00580 72333 6
DSLD Entry Date2020-01-25
Product TypeOther Combinations
FormLiquid
BrandSeeking Health
DSLD ID210961
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.