Home/ Supplements/ Folate/ L-5-MTHF 1,000 mcg

L-5-MTHF 1,000 mcg

product on market Capsule Seeking Health Safety: 60/100
60/100

Review before taking

  • Folate: 1000mg is 1000.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

L-5-MTHF is a bioactive form of folate that supports methylation and homocysteine regulation, with strong evidence for its role in cellular function. However, the low evidence coverage for this specific formulation and a safety score of 60 suggest potential concerns regarding long-term use or specific contraindications.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1000mg is 1000.0× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of folate exceeds the recommended tolerable upper intake level. This means the dosage is significantly higher than the maximum daily limit suggested for safety.

Label

Product Label

Label for L-5-MTHF 1,000 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1000 mcg DFE (250% DV)
Exceeds UL by 1000.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Microcrystalline Cellulose Vegetarian Capsule Ascorbyl Palmitate L-Leucine Silica
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested Use: Take one capsule daily or as directed by your healthcare professional.

Warnings & Precautions

Children and pregnant or lactating women should consult their healthcare professional prior to use.

Children and pregnant or lactating women should consult their healthcare professional prior to use.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach by children.

Formulation Notes

L-5-MTHF delivers a high-potency dose of 1,000 mcg of pure non-racemic L-5-methyltetrahydrofolate in an easy-to-swallow capsule.

Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, GMO, gluten, artificial flavors or artificial colors.

Additional Information

Storage: Keep closed in a cool, dry place out of reach by children.

L-5-MTHF Meets or Exceeds cGMP Standards. Physician Formulated

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This package is completely recyclable

Metadata

Product Details

UPC / SKU7 00580 72357 2
DSLD Entry Date2020-01-25
Product TypeVitamin
FormCapsule
BrandSeeking Health
DSLD ID210849
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.