🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Caplet(s) Serving Size
Botanical with Nutrients Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

33 IU (8% DV)
✅ Within RDA (0.1× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.000825mg UL 0.1mg
3.3 mcg (4% DV)
📊 Market median: 0.1mg (347 products) 📚 273 studies (Tier A: 9, B: 175)
RDA 0.12mg This product: 0.0033mg
Calcium
333 mg (33% DV)
133 mg (33% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 133mg
0.33 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 0.33mg UL 20mg
📊 Market median: 108.0mg (8 products) 📚 9 studies (Tier A: 0, B: 4)
This product: 8.33mg

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Stearic Acid Silica Magnesium Stearate Film coat ingredients

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (54% of products) Approved Health (3% of products)

Target Groups

Adult (18 - 50 Years) Sugar Free

Product Information

📋 Directions for Use

Directions Dr. Perricone recommends taking one packet twice daily with meals. A 30-day program.

⚠️ Warnings & Precautions

Warning: Before using any dietary supplement, pregnant or lactating women should consult with a physician or health professional.

Keep out of the reach of children.

To preserve quality and freshness, store in a cool, dry place at controlled room temperature 15(0)-30(0)C Tamper evident: Do not use if packet is cut, torn, or broken.

🧪 Formulation Notes

Nourishes the body and the skin.

Product Benefits Targeted nutritional supplements are an essential part of Dr. Perricone's 3-Tier philosophy to healthy aging and beautiful skin. This daily program of nutrients is especially designed to support the health of skin. It also supports bone and joint function and healthy hair and nails.

Free of sugar, preservatives, yeast, artificial colors-flavors-dyes.

Additional Information

Each packet contains: 3 softgels, 2 capsules and 3 caplets.

Clinical studies In a 8 week study, 86% reported improved skin texture. 78% reported healthier skin appearance. 65% reported lessening of crow's feet & lines and wrinkles.

Decades of research Perricone MD products are unique in that they are patented, researched and formulated by Nicholas Perricone, M.D., board certified dermatologist and anti-aging expert.

To preserve quality and freshness, store in a cool, dry place at controlled room temperature 15(0)-30(0)C Tamper evident: Do not use if packet is cut, torn, or broken.

This carton is fully recyclable. It's manufactured using wind power and printed in a carbon neutral facility.

Made in USA.

C6 Carbon neutral

Product Details

DSLD Entry Date 2019-11-21
Product Type Botanical with Nutrients
Form Other (e.g. tea bag)
Bundle Skin & Total Body
DSLD ID 209990
Data Updated 2026-04-11

Research Evidence

849 Research Sources
56 Avg Quality Score
450 Meta Analysis
152 Rct
137 Systematic Review
73 Clinical Trial
11 Regulatory Source
7 Other
7 Guideline
3 Openfda Safety
2 Cochrane Review
2 Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021
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