Methyl Folate 400 mcg by Carlson — Ingredients, Evidence & Safety

🟡 60/100

Review before taking

Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
100% of ingredients have research evidence

C Label Compliance Grade

Product Label

📄 Open Full PDF View on NIH DSLD →

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Safety Alerts

⚠️ Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)

This product received a low safety score because the amount of folate it contains significantly exceeds the recommended maximum daily limit.

Label Data

1 Capsule(s) Serving Size

60 Servings

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Folate

400 mcg DFE (100% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 400.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 400mg UL 1.0mg

Other Ingredients

Microcrystalline Cellulose Magnesium Stearate Silicon Dioxide Hypromellose capsule

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Adult (18 - 50 Years) Pregnant Women Lactating Gluten Free

Product Information

📋 Directions for Use

Directions: Adults and pregnant or lactating women: Take one capsule once daily at mealtime.

🧪 Formulation Notes

Quatrefolic

Superior Bioavailability

Prenatal support Women's health

Brain function

Gluten-free No artificial preservatives

Methyl Folate is the active form of folate that bypasses the need for conversion and can be immediately utilized by the body. Methyl Folate plays an important role in prenatal support. Since is crosses the blood-brain barrier, it also provides neurological support.

Additional Information

Potency & quality guaranteed An FDA Regulated Facility

Product Details

UPC / SKU 0 88395 26410 8

DSLD Entry Date 2019-12-22

Product Type Vitamin

Form Capsule

Brand Carlson

DSLD ID 209228

Data Updated 2026-04-11

Research Evidence

363 Research Sources

57 Avg Quality Score

187 Meta Analysis

56 Systematic Review

54 Rct

29 Guideline

26 Clinical Trial

6 Cochrane Review

2 Regulatory Source

1 Other

1 Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021

PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021

PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024

PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022

PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023

PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI

View all evidence for Folate →