Glucosamine & Chondroitin plus Hyaluronic Acid + MSM by 21st Century — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Tablet(s) Serving Size

40 Servings

Other Combinations Product Type

29% Evidence Coverage

Supplement Facts — Evidence Check

Calories

10 Calorie(s)

Total Carbohydrates

2 Gram(s) (1% DV)

Sodium

120 mg (6% DV)

Glucosamine HCl

1500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1500mg

Chondroitin Sulfate

1200 mg

📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)

This product: 1200mg

MSM

500 mg

📊 Market median: 1000.0mg (2 products)

This product: 500mg

Proprietary Blend

60 mg

Other Ingredients

Cellulose Polyplasdone Stearic Acid Contains <2% of

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (90% of products) Nutrient (17% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take one (1) tablet with any meal, up to three (3) times daily or as directed by a healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: If you are diabetic, consult your physician before using this product.

If you have a Shellfish allergy, please consult your physician before using this product.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains shellfish (shrimp, crab, crayfish).

🧪 Formulation Notes

Glucosamine, Chondroitin, MSM (methylsulfonylmethane) and Hyaluronic Acid are important nutrients to help support joints, cartilage and tendons.

No added Sugar, Yeast, Preservatives or Artificial Flavors. Gluten Free.

Contains shellfish (shrimp, crab, crayfish).

Additional Information

Individual results may vary.

Store at room temperature.

Guaranteed quality Laboratory tested

Maximum strength Compare vs. Flex-a-min

Product Details

UPC / SKU 7 40985 27387 6

DSLD Entry Date 2019-09-24

Product Type Other Combinations

Form Tablet or Pill

Brand 21st Century

DSLD ID 207477

Data Updated 2026-04-11

Research Evidence

14 Research Sources

50 Avg Quality Score

9 Rct

3 Clinical Trial

1 Systematic Review

1 Guideline

B Dressings and topical agents containing hyaluronic acid for chronic wound healing

Systematic Review The Cochrane database of systematic reviews 2023

PubMed DOI

B Effect of laughter exercise versus 0.1% sodium hyaluronic acid on ocular surface discomfort in dry eye disease: non-inferiority randomised controlled trial

Rct BMJ (Clinical research ed.) 2024

PubMed DOI

B Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach.

Guideline Aging clinical and experimental research 2026

PubMed DOI

C The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial

Rct Nutrients 2024

PubMed DOI

C Effects of ozone combined with articular injection of sodium hyaluronate on patients with knee osteoarthritis and their inflammatory factors and hemorheological indices.

Rct African health sciences

PubMed DOI

C The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.

Rct Medicine

PubMed DOI

C Liquid combination of hyaluronan, glucosamine, and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain: A randomized controlled study.

Rct Medicine

PubMed DOI

C Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial.

Rct The journal of sexual medicine

PubMed DOI

C PMCF Study to Evaluate Performance and Safety of 'Hyaluronic Acid (HA)-Based Eyedrops' Used to Relieve Dry Eye Symptoms

Clinical Trial ClinicalTrials.gov 2022

ClinicalTrials.gov

C Effect of Hyaluronic Acid Oral Supplementation on Sexual and Urinary Symptoms of Women With Recurrent Urinary Tract Infections

Clinical Trial ClinicalTrials.gov 2022

ClinicalTrials.gov

View all evidence for Hyaluronic Acid →