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Glucosamine & Chondroitin plus Hyaluronic Acid + MSM

product on market Tablet or Pill 21st Century Safety: 90/100
90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 29% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Glucosamine and chondroitin are commonly used to support joint health, though research evidence for their efficacy remains moderate and mixed. MSM is often included to reduce inflammation and joint discomfort. The overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Glucosamine & Chondroitin plus Hyaluronic Acid + MSM
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
40
Servings
Other Combinations
Product Type
29%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s) (1% DV)
Sodium
120 mg (6% DV)
1500 mg
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Market median: 600.0mg (79 products) 25 studies (A:0, B:6)
MSM
500 mg
Market median: 1000.0mg (2 products)
Proprietary Blend
60 mg

Other Ingredients

Cellulose Polyplasdone Stearic Acid Contains <2% of
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, adults take one (1) tablet with any meal, up to three (3) times daily or as directed by a healthcare provider. Do not exceed recommended dosage.

Warnings & Precautions

Do not exceed recommended dosage.

Warning: If you are diabetic, consult your physician before using this product.

If you have a Shellfish allergy, please consult your physician before using this product.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains shellfish (shrimp, crab, crayfish).

Formulation Notes

Glucosamine, Chondroitin, MSM (methylsulfonylmethane) and Hyaluronic Acid are important nutrients to help support joints, cartilage and tendons.

No added Sugar, Yeast, Preservatives or Artificial Flavors. Gluten Free.

Contains shellfish (shrimp, crab, crayfish).

Additional Information

Individual results may vary.

Store at room temperature.

Guaranteed quality Laboratory tested

Maximum strength Compare vs. Flex-a-min

Metadata

Product Details

UPC / SKU7 40985 27387 6
DSLD Entry Date2019-09-24
Product TypeOther Combinations
FormTablet or Pill
Brand21st Century
DSLD ID207477
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
9
Rct
3
Clinical Trial
1
Systematic Review
1
Guideline
B Dressings and topical agents containing hyaluronic acid for chronic wound healing
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
B Effect of laughter exercise versus 0.1% sodium hyaluronic acid on ocular surface discomfort in dry eye disease: non-inferiority randomised controlled trial
Rct BMJ (Clinical research ed.) 2024 PubMed DOI
B Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach.
Guideline Aging clinical and experimental research 2026 PubMed DOI
C The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial
Rct Nutrients 2024 PubMed DOI
C Effects of ozone combined with articular injection of sodium hyaluronate on patients with knee osteoarthritis and their inflammatory factors and hemorheological indices.
Rct African health sciences PubMed DOI
C The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.
Rct Medicine PubMed DOI
C Liquid combination of hyaluronan, glucosamine, and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain: A randomized controlled study.
Rct Medicine PubMed DOI
C Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial.
Rct The journal of sexual medicine PubMed DOI
C PMCF Study to Evaluate Performance and Safety of 'Hyaluronic Acid (HA)-Based Eyedrops' Used to Relieve Dry Eye Symptoms
Clinical Trial ClinicalTrials.gov 2022
C Effect of Hyaluronic Acid Oral Supplementation on Sexual and Urinary Symptoms of Women With Recurrent Urinary Tract Infections
Clinical Trial ClinicalTrials.gov 2022
View all evidence for Hyaluronic Acid →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.