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Fully Active Folate 400 with Quatrefolic 400 mcg

product on market Capsule Doctor's Best Safety: 80/100
80/100

This product is generally safe

  • Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Vitamin C and folate are essential nutrients that support immune function and cellular growth. There is strong evidence for their roles in overall health, though the specific evidence coverage for this formulation is limited. The product maintains a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Fully Active Folate 400 with Quatrefolic 400 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Veggie Capsule(s)
Serving Size
90
Servings
Vitamin
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
40 mg (45% DV)
400 mcg DFE (100% DV)
Exceeds UL by 400.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Microcrystalline Cellulose Modified Cellulose
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Adult Use: Take 1 capsule daily preferably between meals, or as recommended by a nutritionally-informed physician.

Formulation Notes

Doctor’s Best Fully Active Folate 400 with Quatrefolic contains Quatrefolic, the glucosamine salt of (6S)-5-methyltetrahydrofolate, the most bioavailable form of folate, that provides greater stability and water solubility. Our bodies cannot synthesize folate and due to its water-soluble nature, the body stores folate to a limited extent.

Quatrefolic is the metabolically active folate, making it more efficient than folic acid for maximized benefits! Folate is an essential vitamin to support DNA, proper cell division, cardiovascular, mental and emotional well-being. Vitamin C is included for added stability.

Quatrefolic is the most bioavialable form of folate

Non-GMO Gluten free

Vegan

Additional Information

Folic acid, and food folate, needs to be converted to its metabolically active form to be utilized by the body.

Helps support cardiovascular, mental and emotional well-being

YDRB262-3

Helps support healthy mental and emotional well-being

Vegan

Store in a cool dry place.

Metadata

Product Details

UPC / SKU7 53950 00262 3
DSLD Entry Date2019-08-23
Product TypeVitamin
FormCapsule
DSLD ID203311
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.