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Day

product on market Tablet or Pill Natrol Safety: 92/100
92/100

This product looks safe

  • Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

This profile combines B vitamins with 5-HTP and L-Theanine to support mood and cognitive function. There is moderate evidence that these ingredients influence neurotransmitter synthesis and relaxation. However, the overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Day
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (590% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
333 mcg DFE (80% DV)
Exceeds UL by 333.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (2080% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
50 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
50 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)

Other Ingredients

Dibasic Calcium Phosphate Microcrystalline Cellulose Stearic Acid Hypromellose Silicon Dioxide Magnesium Stearate Cellulose Gum Methylcellulose Glycerin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 white tablet, one or two times daily, with food. Do not exceed recommended dose.

Warnings & Precautions

Do not exceed recommended dose.

Keep out of reach of children.

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, or are taking prescription drugs, including drugs for depression, migraines, Parkinson's disease or psychiatric disorders. Do not use with other supplements containing L-Tryptophan or 5-HTP. Do not use if you are pregnant, lactating or under the age of 18 years.

Do not use if you are pregnant, lactating or under the age of 18 years.

Tamper evident packaging. Tablets are sealed in blisters.

Formulation Notes

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, yeast, artificial colors or flavors, added sugar or preservatives

Natrol Stress & Anxiety consists of two separate blends to meet your daytime vs. nighttime needs. The daytime promotes calm and relaxation during the day: 5-HTP supports serotonin which helps enhance moods. Vitamin B-6, B-12 and Folic Acid help maintain emotional well-being. L-Theanine ensures relaxation without making you drowsy

100% drug-free

Vegetarian

Additional Information

Store in a cool, dry place.

Mood & stress Day Promotes calm & relaxation Helps reduce occasional anxiety

Vegetarian

Value size Two 30 tablet blister packs (60 total)

Metadata

Product Details

DSLD Entry Date2019-05-28
Product TypeOther Combinations
FormTablet or Pill
BrandNatrol
DSLD ID203169
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.