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Timed Release Niacin 750 mg

product on market Capsule Rugby Safety: 60/100
60/100

Review before taking

  • Niacin: 750mg is 21.4× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is used to support lipid profiles and cardiovascular health, though research evidence for these effects varies from moderate to limited. Due to a lower safety score, users should be aware of potential concerns such as flushing or liver toxicity. This timed-release formulation aims to reduce these acute reactions.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 750mg is 21.4× the Tolerable Upper Intake Level (35mg)

AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 750mg of Niacin, which is over 21 times the recommended daily upper limit of 35mg.

Label

Product Label

Label for Timed Release Niacin 750 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Captab(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

750 mg (3750% DV)
Exceeds UL by 21.4× (UL: 35 mg) 196 studies (A:5, B:63)

Other Ingredients

Lactose Hypromellose Stearic Acid Titanium Dioxide Magnesium Stearate Magnesium Silicate Triacetin Mineral Oil Sodium Lauryl Sulfate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: Adults only: One captab daily, as a dietary supplement, or as directed by a physician.

Warnings & Precautions

Tamper resistant - Do not use if imprinted safety seal under cap is broken or missing

Contains milk.

Caution: Niacin may cause temporary flushing, itching and tingling, feelings of warmth and headache, particularly when beginning, increasing dose, or changing brand of niacin. These effects seldom require discontinuing niacin use. Skin rash, upset stomach, and low blood pressure when standing are less common symptoms; if they persist, contact a physician.

Warnings: Do not use this product if you have a known sensitivity or allergy to niacin.

Use only under the advice and supervision of a physician if you: have heart disease, recurrent chest pain (angina), or recently suffered a heart attack, are taking high blood pressure or cholesterol-lowering drugs (because of possible drug interactions), have any of the following conditions: gallbladder disease, gout, arterial bleeding, glaucoma, diabetes, impaired liver function, peptic ulcer, or are a pregnant or lactating woman.

Increased uric acid and glucose levels and abnormal liver function tests have been reported in persons taking daily doses of 500 mg or more of niacin. Discontinue use and consult a physician immediately if any of the following symptoms occur: persistent flu-like symptoms (nausea, vomiting, a general “not well” feeling), loss of appetite, a decrease in urine output associated with dark colored urine, muscle discomfort such as tender, swollen muscles or weakness, irregular heartbeat; or cloudy or blurry vision.

Keep out of reach of children.

Formulation Notes

Contains milk.

Caution: Niacin may cause temporary flushing, itching and tingling, feelings of warmth and headache, particularly when beginning, increasing dose, or changing brand of niacin. These effects seldom require discontinuing niacin use.

Free of starch, gluten, sodium, yeast, soy, corn, preservatives, nuts and artificial colors flavors.

Additional Information

To preserve quality and freshness, keep bottle tightly closed. Store between 15(0) - 30(0)C (59(0) - 86(0)F)

Questions or comments? 1-800-645-2158 www.rugbylaboratories.com

Rev. 04/13 R-29 Re-order No. 370108

225

Metadata

Product Details

UPC / SKU0 05367 03301 2
DSLD Entry Date2019-04-25
Product TypeVitamin
FormCapsule
BrandRugby
DSLD ID200429
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.