Glucosamine Chondroitin Complex plus MSM by up&up — Ingredients, Evidence & Safety

Product Label

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Label Data

3 Tablet(s) Serving Size

30 Servings

Other Combinations Product Type

25% Evidence Coverage

Supplement Facts — Evidence Check

Calories

15 {Calories}

Total Carbohydrates

4 g (1% DV)

Sodium

25 mg (1% DV)

Glucosamine Hydrochloride

1.5 g

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1500.0mg

MSM

1.5 g

📊 Market median: 1000.0mg (2 products)

This product: 1500.0mg

Chondroitin Sulfate Sodium

200 mg

📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)

This product: 200mg

Antioxidant Proprietary Extract

250 mg

Hyaluronic Acid

3.3 mg

📊 Market median: 100.0mg (173 products)

Median 100.0mg This product: 3.3mg

Other Ingredients

Microcrystalline Cellulose Hypromellose Croscarmellose Sodium Crospovidone Titanium Dioxide Magnesium Stearate Silicon Dioxide Polyethylene Glycol Polysorbate 80

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

3 tablets per day

Directions: Adults, take three (3) tablets together with a meal once a day.

⚠️ Warnings & Precautions

If taking other dietary supplement, it is best to take this product at a different time of day than those supplements. As a reminder, discuss the supplements and medications you take with your healthcare provider.

CAUTION: If you are pregnant or nursing, or if you take any medication (including OTC medication), or if you have ANY MEDICAL CONDITION or are planning any medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. Keep out of reach of children.

DO NOT USE IF PRINTED SEAL UNDER CAP IS BROKEN OR MISSING

Avoid this product if you have allergies to shellfish or sulfur.

🧪 Formulation Notes

glucosamine and chondroitin

NO: LACTOSE, YEAST, WHEAT, GLUTEN, OR MILK. NO ARTIFICIAL COLORS OR FLAVORS

CONTAINS: SHRIMP, CRAB, CRAYFISH

GLUTEN FREE

Additional Information

smaller, easier-to-swallow tablet

help rebuild cartilage and lubricate joints** hyaluronic acid is a natural component of body tissue and joints

EXP9 14 2MN1494

Store in a cool, dry place, tightly closed.

breakthrough ingredients Antioxidant proprietary extract A dual antioxidant system that helps protect joints from harmful oxidants** Glucosamine and chondroitin Helps rebuild joints** Hyaluronic acid A key tissue and joint component Antioxidant extract Free radical protection** Methylsulfonylmethane (MSM) Provides sulfur which is important for the structural integrity of joint cartilage and connective tissue.**

094 02 0102 : 5C775 UW C3

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THE CONTAINER INSIDE IS FILLED BY COUNT, NOT WEIGHT.

ID201455

Product Details

UPC / SKU 0 70030 62026 4

DSLD Entry Date 2013-03-25

Product Type Other Combinations

Form Tablet or Pill

Brand up&up

DSLD ID 20034

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →