Home/ Supplements/ Folate/ BioCoenzymated Methylfolate 1000 mcg

BioCoenzymated Methylfolate 1000 mcg

product on market Tablet or Pill Natural Factors Safety: 80/100
80/100

This product is generally safe

  • Folate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Methylfolate and Vitamin B12 are essential nutrients that support homocysteine regulation and neurological function. There is strong evidence for their role in maintaining cellular health and supporting fetal development. This combination is generally well-tolerated and safe for most users.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for BioCoenzymated Methylfolate 1000 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1700 mcg DFE (425% DV)
Exceeds UL by 1700.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (2083% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Lactose Microcrystalline Cellulose Croscarmellose Sodium Farm Fresh Factors Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested usage: Chew or dissolve 1 tablet per day in the mouth before swallowing or as directed by a health professional.

Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Contains milk.

Sealed for your protection. Do not use if seal is broken.

Formulation Notes

Quatrefolic is the metabolically active and coenzymated form of folate. The body cannot make folate on its own and must obtain it from foods or dietary supplements. However, folic acid and also food folate are not biologically active and need to be converted to the metabolically active 5-MTHF. Research has shown that Quatrefolic results in a 3.1 times higher blood folate concentration of 5-MTHF that regular folic acid.

BioCoenzymated Methylfolate 1000 mcg plus Methylcobalamin B12 50 mcg Folate + B12

Contains milk.

Contains no artificial colors, preservatives, or sweeteners; no starch, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

Suitable for vegetarians.

Additional Information

isura Non-GMO Mass Spec Documentation Lab Tested

Supports immunity, cardiovascular, neurological, and cognitive health. Helps to support normal early fetal development including the brain and spinal cord, and reduce the risk of neural tube defects when taken daily at least three months prior to becoming pregnant and during early pregnancy. Helps to prevent folate deficiency, produce red blood cells and is a factor in the maintenance of good health. Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada Purity & Potency Guaranteed Recyclable container and label.

The most metabolically active form

Peel back

For freshness, store in a cool, dry place.

R0

This product has passed the most rigorous testing in the world for contaminants and quality. isura.com

What does coenzymated mean? In order for B vitamins to be utilized effectively by the body, they must be converted into their metabolically active coenzyme forms. For example, the coenzyme form of folate is 5-methyltetrahydrofolate (5-MTHF). A coenzyme is a naturally occurring compound that partners with specific enzymes in order to help promote a number of beneficial metabolic reactions in the body. Without the coenzyme, the enzyme cannot promote the biochemical reaction that is responsible for our survival. This dual cooperation between coenzyme and enzyme is a process called coenzymated. Taking B vitamins already in their coenzymated forms allows the body to use them directly. Thus, the amount that is needed by the body is less in order to achieve the same benefits. Biocoenzymated takes it one step further.

The synergy between the phytochemicals found in these plant extracts and the coenzyme B vitamin optimizes absorption. The results? Biocoenzymated delivers the most metabolically active nutrients to your cells to utilize most effectively. Feel the difference.

Metadata

Product Details

UPC / SKU0 68958 01241 4
DSLD Entry Date2018-09-21
Product TypeVitamin
FormTablet or Pill
DSLD ID180898
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.