🟢 80/100

This product is generally safe

  • Folate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1700mg is 1700.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1700 mcg DFE (425% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1700.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1700mg UL 1.0mg
50 mcg (2083% DV)
📊 20.8× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.05mg

Other Ingredients

Lactose Microcrystalline Cellulose Croscarmellose Sodium Farm Fresh Factors Magnesium Stearate

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested usage: Chew or dissolve 1 tablet per day in the mouth before swallowing or as directed by a health professional.

⚠️ Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Contains milk.

Sealed for your protection. Do not use if seal is broken.

🧪 Formulation Notes

Quatrefolic is the metabolically active and coenzymated form of folate. The body cannot make folate on its own and must obtain it from foods or dietary supplements. However, folic acid and also food folate are not biologically active and need to be converted to the metabolically active 5-MTHF. Research has shown that Quatrefolic results in a 3.1 times higher blood folate concentration of 5-MTHF that regular folic acid.

BioCoenzymated Methylfolate 1000 mcg plus Methylcobalamin B12 50 mcg Folate + B12

Contains milk.

Contains no artificial colors, preservatives, or sweeteners; no starch, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

Suitable for vegetarians.

Additional Information

isura Non-GMO Mass Spec Documentation Lab Tested

Supports immunity, cardiovascular, neurological, and cognitive health. Helps to support normal early fetal development including the brain and spinal cord, and reduce the risk of neural tube defects when taken daily at least three months prior to becoming pregnant and during early pregnancy. Helps to prevent folate deficiency, produce red blood cells and is a factor in the maintenance of good health. Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada Purity & Potency Guaranteed Recyclable container and label.

The most metabolically active form

Peel back

For freshness, store in a cool, dry place.

R0

This product has passed the most rigorous testing in the world for contaminants and quality. isura.com

What does coenzymated mean? In order for B vitamins to be utilized effectively by the body, they must be converted into their metabolically active coenzyme forms. For example, the coenzyme form of folate is 5-methyltetrahydrofolate (5-MTHF). A coenzyme is a naturally occurring compound that partners with specific enzymes in order to help promote a number of beneficial metabolic reactions in the body. Without the coenzyme, the enzyme cannot promote the biochemical reaction that is responsible for our survival. This dual cooperation between coenzyme and enzyme is a process called coenzymated. Taking B vitamins already in their coenzymated forms allows the body to use them directly. Thus, the amount that is needed by the body is less in order to achieve the same benefits. Biocoenzymated takes it one step further.

The synergy between the phytochemicals found in these plant extracts and the coenzyme B vitamin optimizes absorption. The results? Biocoenzymated delivers the most metabolically active nutrients to your cells to utilize most effectively. Feel the difference.

Product Details

UPC / SKU 0 68958 01241 4
DSLD Entry Date 2018-09-21
Product Type Vitamin
Form Tablet or Pill
DSLD ID 180898
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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