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St. John's Wort 450 mg

product on market Tablet or Pill Nature Made Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for St. John's Wort 450 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
20
Servings
Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews

Other Ingredients

Cellulose Gel Croscarmellose Sodium Maltodextrin Sodium Starch Glycolate Silicon Dioxide Hypromellose Magnesium Stearate Polyethylene Glycol Stearic Acid
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

1 dose per day

Suggested use: For adults, take two tablets one time daily with water at mealtimes. For easier swallowing, take with water before and during ingestion.

Warnings & Precautions

Keep out of reach of children. Caution: Not for use by children.

If you are pregnant or nursing, consult a health professional before taking this product. There is a possibility St. John's Wort may interact or interfere with some prescription drugs, including blood thinners, oral contraceptives and antidepressants. Consult with your physician or pharmacist before using this product if you are taking any prescription drug, and visit NatureMade.com for additional contraindication information.

Side effects, such as rash, dizziness or nausea, may occur. St. John's Wort is a stimulant and may worsen feelings of anxiety in some people. Psychosis is a rare but possible side effect of take St. John's Wort, particularly in people who have or are at risk for mental health disorders, including bipolar disorder. Limit exposure to the sun as St. John's Wort may cause increased photosensitivity in fair skinned individuals. Discontinue use and consult a health care provider if you experience any side effects. Do not use if imprinted seal under cap is broken or missing.

Formulation Notes

St. John's Wort 450 mg extract

No color added No artificial flavors No preservatives No yeast Gluten free

Additional Information

#1 pharmacist recommended

List No. 14159 L201 Cat. A546 5J030

Guaranteed Purity Quality

Keep bottle tightly closed. Store in a cool, dry place.

St. John's Wort tablets are made to Nature Made's guaranteed purity and potency standards. Based on Pharmacy Times Survey of Pharmacist Recommending Herbal Supplements.

Metadata

Product Details

UPC / SKU3 31604 14159 3
DSLD Entry Date2018-09-21
Product TypeBotanical
FormTablet or Pill
DSLD ID180412
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.