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Homocysteine Regulators

product on market Capsule NOW Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 75% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B6, B12, and folic acid are supported by strong evidence for lowering homocysteine levels in the blood. Trimethylglycine further assists this process by acting as a methyl donor. Overall, these ingredients are well-researched for their role in supporting cardiovascular and neurological health through homocysteine regulation.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Homocysteine Regulators
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

13 mg (650% DV)
10.0× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
250 mcg (4167% DV)
104.2× RDA — above typical dose 139 studies (A:1, B:44)
800 mcg (200% DV)
2.0× RDA — within safe limits 226 studies (A:10, B:105)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Cellulose Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

SUGGESTED USAGE: As a dietary supplement for adults, take 1 capsule 1 to 2 times daily, preferably with food.

Warnings & Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do Not Eat Freshness Packet. Keep in Bottle.

Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

B-6, B-12, Folic Acid and TMG

Vegetarian/Vegan

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Additional Information

This combination of key B-vitamins may aid the body’s regulation of homocysteine, a potentially harmful byproduct of protein metabolism.*

Store in a cool, dry place after opening.

Please Recycle.

CAPSULE SIZE Made in the USA

CARDIOVASCULAR SUPPORT

Promotes Healthy Heart Function*

GMP QUALITY ASSURED

For more product information visit www.nowfoods.com/3305

CODE 3305T V2

Metadata

Product Details

UPC / SKU7 33739 03305 5
DSLD Entry Date2012-11-21
Product TypeOther Combinations
FormCapsule
BrandNOW
DSLD ID14998
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.