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  • Niacin: 1000mg is 28.6× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Niacin: 1000mg is 28.6× the Tolerable Upper Intake Level (35mg)

The safety score is low because the 1000mg dose of Niacin is significantly higher than the recommended maximum daily limit of 35mg.

Label Data

1 Capsule(s) Serving Size
100 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1000 mg
⚠️ Exceeds Tolerable Upper Intake Level by 28.6× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 1000mg UL 35mg

Other Ingredients

Gelatin Vegetable Stearate

Label Claims — Verification

All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Dosage and Use Take one capsule daily with meals, or as recommended by a healthcare practitioner.

⚠️ Warnings & Precautions

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Caution Temporary flushing, itching, rash, or gastric disturbances may occur. Liver function testing is recommended when niacin is taken in excess of 500 mg daily. Those with gout or liver diseases should avoid taking high doses of niacin.

Warnings - KEEP OUT OF REACH OF CHILDREN.

- DO NOT EXCEED RECOMMENDED DOSE.

- Do not purchase if outer seal is broken or damaged.

🧪 Formulation Notes

This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Vitamin B3 Niacin 1000 mg, 100 capsules

Additional Information

Note Niacinamide is another B3 vitamin that does not cause flushing.

Niacin is the only B vitamin that can be synthesized in the liver from the amino acid tryptophan — on average, 1 mg of niacin can be synthesized from the ingestion of 60 mg of tryptophan.148-150 In its coenzyme forms, niacin is crucial to energy transfer reactions, particularly the metabolism of glucose, fat, and alcohol.151,152 Niacin’s beneficial effects on blood lipids is well-documented.153-166

Promotes Cardiovascular Health

Product Details

DSLD Entry Date 2012-10-01
Product Type Vitamin
Form Capsule
DSLD ID 13460
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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