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Osteo Bi-Flex Advanced

product on market Other (e.g. tea bag) Osteo Bi-Flex Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 17% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Glucosamine HCl and manganese are commonly used to support joint health, though research evidence for their efficacy remains moderate to limited. Vitamin C provides antioxidant support and aids in collagen synthesis. The product maintains a high safety profile with no significant concerns noted for these ingredients.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Osteo Bi-Flex Advanced
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Caplet(s)
Serving Size
37
Servings
Other Combinations
Product Type
17%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
60 mg (100% DV)
2 mg (100% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
Sodium
40 mg (2% DV)
1500 mg
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Joint Shield(TM) Proprietary Blend
1350 mg
3 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews

Other Ingredients

Crospovidone Cellulose Coating Titanium Dioxide color Cellulose Silica Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS FOR ADULT USE: TAKE TWO (2) CAPLETS PER DAY WITH FOOD. As a reminder, discuss the supplements and medications you take with your health care providers. Note: You have the option of taking two caplets together or spread throughout the day.

Warnings & Precautions

Not intended for use by persons under the age of 18.

CAUTION: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Formulation Notes

Contains shellfish (shrimp, crab, lobster, crayfish) ingredients.

Additional Information

Helps to: Promote Mobility* Renew Cartilage* Maintain Healthy Connective Tissue* Based on the results of the National Disease and Therapeutic Index syndicated report among physicians who recommend a branded Glucosamine/Chondroitin or Glucosamine supplement, December 2009, and the results of the Pharmacy Times Survey among pharmacists who recommend a “bone/joint strengthener” dietary supplement, 2010. 1. This statement is based on two human studies of 5-LOXIN Advanced™ using subjective measures in which participants rate their joint health. In these studies, after 7 days, improvement continued to be seen, including in biomarker analysis.

ADVANCED SHOWS IMPROVEMENT IN Joint Comfort within 7 Days!1

STORE IN A DRY PLACE AND AVOID EXCESSIVE HEAT.

40 points

15471 08E B31357 MAZ

THE NATURAL AGING PROCESS CAN ADD EXCESSIVE STRESS ON YOUR JOINTS. ANNOYING FLARE-UPS CAN STRIKE AT ANY TIME. NOW THERE’S A DIFFERENT CHOICE TO SUPPORT HEALTHY JOINTS.

#1 DOCTOR & PHARMACIST RECOMMENDED BRAND

PROUD SPONSOR of the

ARTHRITIS FOUNDATION(R)

For information about arthritis, contact the Foundation at 1-800-568-4045 or www.arthritis.org

Part No. 22-15747

Metadata

Product Details

UPC / SKU0 30768 15471 4
DSLD Entry Date2012-06-25
Product TypeOther Combinations
FormOther (e.g. tea bag)
BrandOsteo Bi-Flex
DSLD ID10335
Data Updated2026-04-11
Research

Research Evidence

371
Research Sources
54
Avg Quality
148
Meta Analysis
82
Systematic Review
71
Rct
62
Clinical Trial
2
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Other
1
Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024 PubMed DOI
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021 PubMed DOI
View all evidence for Vitamin C →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.