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Menopause Formula

product on market Capsule GNC Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Black cohosh and soy isoflavones are commonly used to manage menopausal symptoms, though research evidence for their efficacy is generally considered moderate to limited. These ingredients aim to reduce hot flashes and night sweats by modulating hormonal responses. The formula maintains a high safety profile based on available data.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Menopause Formula
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Botanical
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 80.0mg (136 products)
Market median: 60.0mg (94 products) 13 studies (A:0, B:7)
Isolase(R)
35 mg

Other Ingredients

Cellulose Gelatin Maltodextrin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one capsule daily.

Warnings & Precautions

CONTAINS: Soybeans and Wheat.

KEEP OUT OF REACH OF CHILDREN.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition. Discontinue use two weeks prior to surgery.

Formulation Notes

160 mg of black cohosh root extract

MENOPAUSE FORMULA GNC Women’s Menopause Formula is specially formulated with standardized soy Isoflavones, Isolase(R) and black cohosh for women seeking support for menopause. Soy Isoflavones • Act as mild estrogens and may help manage hot flashes and night sweats associated with menopause.* Emerging research reveals that Isoflavones may also have the ability to help maintain bone density,* another common concern of women during menopause. The best known isoflavones are genistein and daidzein. Isolase(R) • A patented enzyme system; laboratory studies indicate its ability to significantly increase the availability of soy Isoflavones.* Based on laboratory studies combining 35 mg of Isolase(R) with 100 mg total isoflavones for 1 hr. The increase in the level of genistein and daidzein in each sample was the measured by high performance liquid chromatography (HPLC). A 12.8 fold increase in genistein and 10.5 fold increase in daidzein were observed. Black cohosh • A popular herb studied in German clinical trials and frequently recommended for hot flashes.*

No Sugar, No Artificial Colors, No Artificial Flavors, Sodium Free, No Gluten, No Dairy, Yeast Free.

Additional Information

Store in a cool, dry place.

ACTUAL SIZE

CODE 296511 JLG

Conforms to USP <2091> for weight.

GNC QUALITY COMMITMENT GNC is the leader in the development and manufacture of dietary supplements, committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend out quality commitment to you by offering our money-back guarantee.

May help provide support for hot flashes and night sweats*

Meets USP <2040> disintegration.

Please recycle this box.

Standardized soy isoflavones

U.S. Patent Nos. 6,642,212; 6,664,382; 6,323,018; 6,495,141; 5,990,291; 6,680,381 and 6,562,380.

Metadata

Product Details

DSLD Entry Date2011-10-26
Product TypeBotanical
FormCapsule
BrandGNC
DSLD ID992
Data Updated2026-04-11
Research

Research Evidence

31
Research Sources
49
Avg Quality
23
Systematic Review
5
Meta Analysis
1
Rct
1
Openfda Safety
B [Efficacy of black cohosh extracts for improving low estrogen status induced by postoperative GnRHa treatment in patients with endometriosis: a systematic review]
Systematic Review Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2020 PubMed
B Black cohosh (Cimicifuga spp.) for menopausal symptoms
Meta Analysis The Cochrane database of systematic reviews 2012 PubMed DOI
B Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause
Systematic Review BJOG : an international journal of obstetrics and gynaecology 2017 PubMed DOI
C Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract
Meta Analysis Menopause (New York, N.Y.) 2011 PubMed DOI
C Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence
Meta Analysis Climacteric : the journal of the International Menopause Society 2021 PubMed DOI
C Menopausal symptoms
Systematic Review BMJ clinical evidence 2007 PubMed
C Menopausal symptoms
Systematic Review BMJ clinical evidence 2011 PubMed
C Menopausal symptoms
Systematic Review BMJ clinical evidence 2010 PubMed
C Black cohosh extracts in women with menopausal symptoms: an updated pairwise meta-analysis
Meta Analysis Menopause (New York, N.Y.) 2023 PubMed DOI
C Efficacy of black cohosh-containing preparations on menopausal symptoms: a meta-analysis
Meta Analysis Alternative therapies in health and medicine 2010 PubMed
View all evidence for Black Cohosh →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.