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Glucosamine Chondroitin Sulfate

product on market Softgel Capsule The Vitamin Shoppe Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

D-glucosamine HCl and chondroitin sulfate are commonly used to support joint health and cartilage function. Research provides moderate evidence that these ingredients may help manage joint discomfort, though results vary across studies. The current evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Glucosamine Chondroitin Sulfate
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Softgel(s)
Serving Size
40
Servings
Non-Nutrient/Non-Botanical
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
25 Calorie(s)
Total Fat
2.5 Gram(s) (3% DV)
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Market median: 600.0mg (79 products) 25 studies (A:0, B:6)

Other Ingredients

Soybean Oil Gelatin Glycerin purified Water Soy Lecithin Carob extract Titanium Dioxide yellow Beeswax
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take three (3) softgels three times daily, preferably with meals.

Warnings & Precautions

Contains: Soy and Crustacean Shellfish (shrimp, crab).

Warning: Do not use this product if you are allergic to shellfish or sulfur.

Consult your physician prior to use if you are diabetic.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Formulation Notes

Gluten free Dairy free Nut free

Contains: Soy and Crustacean Shellfish (shrimp, crab).

Does Not Contain: Wheat, gluten, salt, dairy, citrus, fish, artificial colors or flavors.

Additional Information

Easy to swallow Joint Mobility Flexibility Specialty

Actual size

Store in a cool, dry place.

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

Item No. VS-3398 2022911 ER 6

Metadata

Product Details

UPC / SKU7 66536 03398 0
DSLD Entry Date2017-11-20
Product TypeNon-Nutrient/Non-Botanical
FormSoftgel Capsule
BrandThe Vitamin Shoppe
DSLD ID80391
Data Updated2026-04-11
Research

Research Evidence

33
Research Sources
48
Avg Quality
21
Rct
10
Meta Analysis
2
Clinical Trial
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023 PubMed DOI
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006 PubMed
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022 PubMed DOI
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016 PubMed DOI
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018 PubMed DOI
C Update on the role of pharmaceutical-grade chondroitin sulfate in the symptomatic management of knee osteoarthritis
Meta Analysis Aging clinical and experimental research 2019 PubMed DOI
C Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Inflammopharmacology 2024 PubMed DOI
C Does incorporating collagen and chondroitin sulfate matrix in implant surfaces enhance osseointegration? A systematic review and meta-analysis
Meta Analysis International journal of oral and maxillofacial surgery 2018 PubMed DOI
C Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials
Meta Analysis Rheumatology international 2018 PubMed DOI
View all evidence for Chondroitin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.