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5-HTP 50 mg

product on market Capsule Highland Laboratories Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-HTP is used to support serotonin levels, while Vitamin B6 and Niacin act as enzymatic cofactors in neurotransmitter synthesis. Research provides moderate evidence for the efficacy of 5-HTP in mood regulation. However, overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 50 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg (25% DV)
Within RDA (0.4× RDA) 196 studies (A:5, B:63)
10 mg (500% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
50 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Enhance Calcium Phosphate Vegetable Cellulose Cellulose Magnesium Trisilicate Silica
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

One capsule daily, as a dietary supplement.

Formulation Notes

No soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives.

Formulated with Enhance metabolite uptake enhancers. Contains citrus products.

Additional Information

Also available in 90 count

Serotonin support

GMP Quality Assured Earth Friendly

% Daily Value

Enzyme co-factors B-6 and Niacin are associated with serotonin production.

PR 1328

Metadata

Product Details

UPC / SKU7 68305 13283 2
DSLD Entry Date2017-10-21
Product TypeOther Combinations
FormCapsule
BrandHighland Laboratories
DSLD ID79888
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.