🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

Calcium
43 mg (4% DV)
Protein
1 Gram(s) (2% DV)
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 750mg

Other Ingredients

Dibasic Calcium Phosphate Stearic Acid Microcrystalline Cellulose modified Cellulose Gum Magnesium Stearate Silica

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested Use: For daily maintenance, take 1 to 2 tablets. To support lower homocysteine levels, take 2 to 4 tablets daily. Additional benefits may be obtained by taking this product with other methyl donor supplements such as vitamin B-6, vitamin B-12 and folic acid.

⚠️ Warnings & Precautions

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

🧪 Formulation Notes

(Anhydrous betaine)

Suitable for Vegetarians and Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat.

Suitable for Vegetarians and Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat.

Suitable for Vegetarians and Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Additional Information

TMG, also known as anhydrous betaine, is found in a variety of plant and animal sources and is used in the conversion of homocysteine to methionine. Maintaining normal homocysteine levels is important for the health of the cardiovascular system. TMG has been shown to help protect the liver and raise S-adenosylmethionine (SAM) levels, in animal studies. SAM may help to promote a balanced emotional state.

SN0876 REV D112

Product Details

UPC / SKU 0 21078 00876 7
DSLD Entry Date 2018-01-25
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 78067
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
View all evidence for Betaine →

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