Home/ Supplements/ Betaine/ TMG Trimethylglycine 750 mg

TMG Trimethylglycine 750 mg

product on market Tablet or Pill Source Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for TMG Trimethylglycine 750 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Other Combinations
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calcium
43 mg (4% DV)
Protein
1 Gram(s) (2% DV)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Dibasic Calcium Phosphate Stearic Acid Microcrystalline Cellulose modified Cellulose Gum Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: For daily maintenance, take 1 to 2 tablets. To support lower homocysteine levels, take 2 to 4 tablets daily. Additional benefits may be obtained by taking this product with other methyl donor supplements such as vitamin B-6, vitamin B-12 and folic acid.

Warnings & Precautions

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Formulation Notes

(Anhydrous betaine)

Suitable for Vegetarians and Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat.

Suitable for Vegetarians and Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat.

Suitable for Vegetarians and Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Additional Information

TMG, also known as anhydrous betaine, is found in a variety of plant and animal sources and is used in the conversion of homocysteine to methionine. Maintaining normal homocysteine levels is important for the health of the cardiovascular system. TMG has been shown to help protect the liver and raise S-adenosylmethionine (SAM) levels, in animal studies. SAM may help to promote a balanced emotional state.

SN0876 REV D112

Metadata

Product Details

UPC / SKU0 21078 00876 7
DSLD Entry Date2018-01-25
Product TypeOther Combinations
FormTablet or Pill
DSLD ID78067
Data Updated2026-04-11
Research

Research Evidence

23
Research Sources
47
Avg Quality
18
Rct
3
Systematic Review
1
Meta Analysis
1
Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016 PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023 PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019 PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.