Phosphatidyl Choline 385 mg by The Vitamin Shoppe — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
25% of ingredients have research evidence

B Label Compliance Grade

Product Label

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Label Data

1 Softgel(s) Serving Size

100 Servings

Fat/Fatty Acid Product Type

25% Evidence Coverage

Supplement Facts — Evidence Check

Calories

10 Calorie(s)

Calories from Fat

10 Calorie(s)

Total Fat

1 Gram(s)

Phosphatidyl Choline

385 mg

✅ Within RDA (0.7× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)

RDA 550mg This product: 385mg UL 3500mg

Other Ingredients

Gelatin Glycerin Medium Chain Triglycerides purified Water

Label Claims — Verification

❓ All Other

All Other (97% of products) Structure/Function (90% of products) Nutrient (42% of products)

Target Groups

Adult (18 - 50 Years) Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions As a dietary supplement, take one (1) to three (3) softgels daily, preferably with meals.

⚠️ Warnings & Precautions

Contains soy

Warning Keep out of reach of children.

🧪 Formulation Notes

Contains soy

No; yeast, corn, wheat, sugar, salt, starch, dairy, citrus, fish

Does Not Contain: Yeast, corn, wheat, sugar, salt, starch, dairy, citrus, fish, preservatives, artificial colors or flavors added.

Additional Information

Natural food supplement

Essential for healthy liver function

Dietary Supplement

About this product One of the phospholipids found in high concentrations in the brain, reported in studies as being able to improve memory, learning, concentration, word recall, and mood in middle-aged and elderly persons with dementia or decreased cognitive function. Has been used to support memory and cognitive function in individuals with mild to moderate faulty memory due to age.

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Product Details

DSLD Entry Date 2017-05-24

Product Type Fat/Fatty Acid

Form Softgel Capsule

Brand The Vitamin Shoppe

DSLD ID 73889

Data Updated 2026-04-11

Research Evidence

28 Research Sources

47 Avg Quality Score

11 Clinical Trial

8 Rct

2 Guideline

2 Meta Analysis

2 Regulatory Source

1 Systematic Review

1 Openfda Safety

B Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis

Meta Analysis Biological psychiatry. Cognitive neuroscience and neuroimaging 2024

PubMed DOI

B Integrating multi-structure covalent docking with machine-learning consensus scoring enhances potency ranking of human acetylcholinesterase inhibitors.

Guideline Briefings in bioinformatics 2026

PubMed DOI

B Evidence-based clinical practice guidelines for functional dyspepsia 2021.

Guideline Journal of gastroenterology 2022

PubMed DOI

B Scientific Opinion on health claims related to choline

Regulatory Source EFSA Journal 2011

DOI

C Effectiveness of nutritional interventions to prevent nonprogressive congenital and perinatal brain injuries: a systematic review and meta-analysis of randomized trials

Meta Analysis Nutrition reviews 2022

PubMed DOI

C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.

Rct The American journal of clinical nutrition

PubMed DOI

C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.

Rct The American journal of clinical nutrition

PubMed DOI

C Nutrient-based therapies for bipolar disorder: a systematic review

Systematic Review Psychotherapy and psychosomatics 2013

PubMed DOI

C The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people

Rct The British journal of nutrition 2007

PubMed

C Differential metabolism of choline supplements in adult volunteers.

Rct European journal of nutrition

PubMed DOI

View all evidence for Choline →