🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

Product Label

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Label Data

1 Softgel(s) Serving Size
Other Combinations Product Type
25% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Fat
0.5 Gram(s) (1% DV)
400 mg
📊 Market median: 500.0mg (234 products) 📚 95 studies (Tier A: 0, B: 35)
This product: 400mg
MCT (Medium Chain Triglycerides) Oil
700 mg

Other Ingredients

Softgel Capsule Beeswax Sunflower Lecithin

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (86% of products) Nutrient (4% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage: Take 1 softgel 3 times daily with food, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Cautions/Interactions: Do not use if you are pregnant, may become pregnant, or are breast feeding.

This product may cause mild gastrointestinal discomfort.

If you are taking medications (especially anti-diabetes medications, CYP3A4 substrates such as cyclosporine, CYP2D6 substrates, or CYP2C9 substrates such as dextromethorphan) or have a medical condition, consult your healthcare practitioner prior to use.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

How It Works: Berberine is a natural constituent of herbs such as goldenseal, Oregon grape, and barberry. Clinical studies have demonstrated that Berberine helps to support already normal glucose and lipid metabolism.* Berberine is, however, known for its limited bioavailability; therefore, this product includes Caprate (C10, a Medium Chain Triglyceride) to promote optimal absorption and maintenance of gastrointestinal comfort during Berberine supplementation.*

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

Additional Information

Natural color variation may occur in this product.

CODE P4600 V2

~ Supports glucose and lipid levels already within the normal range* ~ Optimal berberine absorption and GI tolerability

Product Details

UPC / SKU 7 07359 14600 6
DSLD Entry Date 2017-05-24
Product Type Other Combinations
Form Softgel Capsule
DSLD ID 73468
Data Updated 2026-04-11

Research Evidence

98 Research Sources
55 Avg Quality Score
48 Systematic Review
39 Meta Analysis
4 Rct
4 Clinical Trial
1 Other
1 Narrative Review
1 Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025
View all evidence for Berberine →

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