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Glucose Management With Berberine HCl

product on market Softgel Capsule Protocol For Life Balance Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Berberine HCl is supported by strong evidence for helping to manage blood glucose levels and improve insulin sensitivity. MCT oil provides a source of rapid energy and may support metabolic function. Together, these ingredients target glucose metabolism, though overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Glucose Management With Berberine HCl
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
Other Combinations
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Fat
0.5 Gram(s) (1% DV)
400 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)
MCT (Medium Chain Triglycerides) Oil
700 mg

Other Ingredients

Softgel Capsule Beeswax Sunflower Lecithin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Take 1 softgel 3 times daily with food, or as directed by your healthcare practitioner.

Warnings & Precautions

Cautions/Interactions: Do not use if you are pregnant, may become pregnant, or are breast feeding.

This product may cause mild gastrointestinal discomfort.

If you are taking medications (especially anti-diabetes medications, CYP3A4 substrates such as cyclosporine, CYP2D6 substrates, or CYP2C9 substrates such as dextromethorphan) or have a medical condition, consult your healthcare practitioner prior to use.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

How It Works: Berberine is a natural constituent of herbs such as goldenseal, Oregon grape, and barberry. Clinical studies have demonstrated that Berberine helps to support already normal glucose and lipid metabolism.* Berberine is, however, known for its limited bioavailability; therefore, this product includes Caprate (C10, a Medium Chain Triglyceride) to promote optimal absorption and maintenance of gastrointestinal comfort during Berberine supplementation.*

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

Additional Information

Natural color variation may occur in this product.

CODE P4600 V2

~ Supports glucose and lipid levels already within the normal range* ~ Optimal berberine absorption and GI tolerability

Metadata

Product Details

UPC / SKU7 07359 14600 6
DSLD Entry Date2017-05-24
Product TypeOther Combinations
FormSoftgel Capsule
DSLD ID73468
Data Updated2026-04-11
Research

Research Evidence

98
Research Sources
55
Avg Quality
48
Systematic Review
39
Meta Analysis
4
Rct
4
Clinical Trial
1
Other
1
Narrative Review
1
Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 PubMed DOI
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019 PubMed DOI
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023 PubMed DOI
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024 PubMed DOI
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019 PubMed DOI
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025 PubMed DOI
View all evidence for Berberine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.