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Berberine 400 mg

product on market Softgel Capsule LuckyVitamin Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Berberine HCl is supported by moderate to strong evidence for helping manage blood glucose levels and metabolic health. MCT oil provides a quick energy source and may support cognitive function. Overall, the evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Berberine 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
90
Servings
Other Combinations
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Fat
0.5 Gram(s) (1% DV)
400 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)
MCT Oil
700 mg

Other Ingredients

Bovine Gelatin Glycerin Water Caramel color Beeswax Sunflower Lecithin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Take 1 softgel 3 times daily with food.

Warnings & Precautions

Caution: For adults only.

Do not use if you are pregnant, may become pregnant, or are breastfeeding. This product may cause mild gastrointestinal discomfort. If you are taking medications (especially anti-diabetes medications) or have a medical condition, consult your physician prior to use.

Keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

Berberine is a natural constituent of herbs such as goldenseal, Oregon grape, and barberry. Clinical studies have demonstrated that berberine helps to support already normal glucose and lipid metabolism. Because berberine is known for its limited bioavailability, this product includes caprate (C10), a medium-chain triglyceride) to promote optimal absorption and maintenance of gastrointestinal comfort during berberine supplementation.

Natural color variation may occur in this product.

Supports glucose and lipid levels already within the normal range

With MCT Oil for optimal absorption

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

Additional Information

1 year happiness guarantee

Store in a cool, dry place after opening.

Guaranteed Quality & Potency

Metadata

Product Details

UPC / SKU8 10026 42035 1
DSLD Entry Date2023-02-21
Product TypeOther Combinations
FormSoftgel Capsule
DSLD ID283107
Data Updated2026-04-11
Research

Research Evidence

98
Research Sources
55
Avg Quality
48
Systematic Review
39
Meta Analysis
4
Rct
4
Clinical Trial
1
Other
1
Narrative Review
1
Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 PubMed DOI
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019 PubMed DOI
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023 PubMed DOI
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024 PubMed DOI
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019 PubMed DOI
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025 PubMed DOI
View all evidence for Berberine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.