Glucosamine Chondroitin Complex Plus MSM by 21st Century — Ingredients, Evidence & Safety

Product Label

📄 Open Full PDF View on NIH DSLD →

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

3 Tablet(s) Serving Size

25 Servings

Other Combinations Product Type

22% Evidence Coverage

Supplement Facts — Evidence Check

Calories

15 Calorie(s)

Total Carbohydrates

3 Gram(s) (1% DV)

Vitamin C

60 mg (100% DV)

Manganese

2 mg (100% DV)

✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 2mg UL 11mg

Sodium

50 mg (2% DV)

Glucosamine HCl

1500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1500mg

Proprietary Blend

1250 mg

Boswellia serrata extract

100 mg

📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)

This product: 100mg

Boron

3 mg

📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews

This product: 3mg UL 20mg

Other Ingredients

Cellulose Stearic Acid Silicon Dioxide Polyplasdone Magnesium Stearate Polydextrose Titanium Dioxide PEG Artificial colors

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Sugar Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take up to three (3) tablets daily after meals, or as directed by your healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Do not exceed recommended dosage. Warning: If you are diabetic, consult your physician before using this product.

If you have a Shellfish allergy please consult your physician before using this product.

KEEP OUT OF REACH OF CHILDREN.

Do not use if product appears to be tampered with or seal is broken.

Contains: Shrimp, Crab, Crayfish.

🧪 Formulation Notes

No Sugar, Preservatives or Artificial Flavors.

Contains: Shrimp, Crab, Crayfish.

Glucosamine & Chondroitin Complex Double Strength combines these two nutritional elements in the proper amounts for your effective use.

Additional Information

Store at room temperature.

Guaranteed Quality Laboratory Tested

0614

Advanced Double Strength

Many recent scientific studies have shown the effectiveness of taking supplements with the proper combination of Glucosamine HCI and Chondroitin Sulfate. These compounds found in the soft cartilage, tendons and synovial fluid, are essential to the healthy functioning of tendons and joints, especially with advancing age.*

Product Details

UPC / SKU 7 40985 27289 3

DSLD Entry Date 2016-10-22

Product Type Other Combinations

Form Tablet or Pill

Brand 21st Century

DSLD ID 66131

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →