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Knock-Out

product on market Tablet or Pill Schiff Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 62% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Melatonin and magnesium have moderate to strong evidence for supporting sleep onset and quality. Glycine and vitamin B6 further assist in relaxation and neurotransmitter regulation. Overall, these ingredients are well-supported by research for promoting restful sleep.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Knock-Out
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Other Combinations
Product Type
62%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

0.5 mg (25% DV)
Within RDA (0.4× RDA) 114 studies (A:3, B:35)
Calcium
200 mg (20% DV)
10 mg (3% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
3 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)
Glycine
40 mg
50 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
Market median: 300.0mg (214 products) 25 studies (A:0, B:6)
Gamma-Aminobutyric Acid
100 mg

Other Ingredients

Cellulose Stearic Acid Croscarmellose Sodium Silicon Dioxide Hydroxypropyl Methylcellulose Magnesium Stearate Food Glaze Maltodextrin Polyethylene Glycol
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: For best results, take one (1) tablet at bedtime or as recommended by a health care professional.

Warnings & Precautions

WARNING: Not intended for use by pregnant or lactating women, individuals with autoimmune conditions, depressive disorders, endocrine disorders, serious illness, or other drug use. Seek advice from your health practitioner prior to use if under medical supervision, taking tranquilizers or sedatives or taking more than 10 mg of melatonin per day.

Do not use before or while operating a motor vehicle or heavy machinery.

Not to be taken by individuals under the age of 18.

Keep out of reach of children.

Formulation Notes

3mg Melatonin & More

With Theanine & Valerian

GUARANTEED: No added sugar (sucrose, fructose, lactose), salt (sodium chloride), yeast, wheat, gluten or milk. No preservatives, artificial colors or artificial flavors.

Knock-Out is also drug free.

Knock Out contains melatonin to help maintain regular sleep patterns and Valerian extract and Theanine to promote relaxation.

Additional Information

NOTE: Valerian extract has a naturally occurring pungent odor.

Over 75 years of wellness

New look

Supports relaxation & normal sleep patterns

Since 1936

For information call: 1-800-526-6251 (8am-5pm MST M–F)

Schiff Quality Guarantee

GUARANTEED for purity, freshness and labeled potency.

Store in a cool, dry place with lid tightly closed.

12782 46612782.13

Metadata

Product Details

UPC / SKU0 20525 12782 2
DSLD Entry Date2016-10-22
Product TypeOther Combinations
FormTablet or Pill
BrandSchiff
DSLD ID65627
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.