🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 62% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
62% Evidence Coverage

Supplement Facts — Evidence Check

0.5 mg (25% DV)
✅ Within RDA (0.4× RDA of 1.3 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 0.5mg UL 100mg
Calcium
200 mg (20% DV)
10 mg (3% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 10mg
3 mg
📊 Market median: 3.0mg (984 products) 📚 236 studies (Tier A: 2, B: 109)
This product: 3mg UL 10mg
Glycine
40 mg
50 mg
📊 Market median: 200.0mg (358 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 50mg
📊 Market median: 300.0mg (214 products) 📚 23 studies (Tier A: 0, B: 6)
This product: 100mg
Gamma-Aminobutyric Acid
100 mg

Other Ingredients

Cellulose Stearic Acid Croscarmellose Sodium Silicon Dioxide Hydroxypropyl Methylcellulose Magnesium Stearate Food Glaze Maltodextrin Polyethylene Glycol

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: For best results, take one (1) tablet at bedtime or as recommended by a health care professional.

⚠️ Warnings & Precautions

WARNING: Not intended for use by pregnant or lactating women, individuals with autoimmune conditions, depressive disorders, endocrine disorders, serious illness, or other drug use. Seek advice from your health practitioner prior to use if under medical supervision, taking tranquilizers or sedatives or taking more than 10 mg of melatonin per day.

Do not use before or while operating a motor vehicle or heavy machinery.

Not to be taken by individuals under the age of 18.

Keep out of reach of children.

🧪 Formulation Notes

3mg Melatonin & More

With Theanine & Valerian

GUARANTEED: No added sugar (sucrose, fructose, lactose), salt (sodium chloride), yeast, wheat, gluten or milk. No preservatives, artificial colors or artificial flavors.

Knock-Out is also drug free.

Knock Out contains melatonin to help maintain regular sleep patterns and Valerian extract and Theanine to promote relaxation.

Additional Information

NOTE: Valerian extract has a naturally occurring pungent odor.

Over 75 years of wellness

New look

Supports relaxation & normal sleep patterns

Since 1936

For information call: 1-800-526-6251 (8am-5pm MST M–F)

Schiff Quality Guarantee

GUARANTEED for purity, freshness and labeled potency.

Store in a cool, dry place with lid tightly closed.

12782 46612782.13

Product Details

UPC / SKU 0 20525 12782 2
DSLD Entry Date 2016-10-22
Product Type Other Combinations
Form Tablet or Pill
Brand Schiff
DSLD ID 65627
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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