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5-HTP 100 mg

product on market Capsule Solgar Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-HTP, magnesium, and vitamin B6 are supported by moderate evidence for supporting mood and sleep regulation. Valerian extract is commonly used for relaxation, though research evidence for its efficacy is more limited. This combination focuses on neurotransmitter synthesis and nervous system support.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetable Capsule(s)
Serving Size
Botanical with Nutrients
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
50 mg (12% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
Market median: 300.0mg (214 products) 25 studies (A:0, B:6)

Other Ingredients

Vegetable Cellulose Microcrystalline Cellulose Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usse: As a dietary supplement for adults, take one (1) vegetable capsule twice daily as needed or at bedtime as 5-HTP may produce drowsiness or as directed by a healthcare practitioner. If you experience stomach sensitivity, take with food.

Warnings & Precautions

Not intended for use by pregnant or nursing women. If you are taking any medications, including anti-depressants or drugs with central nervous system or serotonergic activity, or have any medical condition, including mental health or gastrointestinal concerns, consult your healthcare practitioner before use.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur. Do not drive, operate machinery or consume alcohol when taking this product.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Formulation Notes

Free Of: Gluten, Wheat, Dairy, Soy, Yeast, Sugar, Sodium, Artificial Flavor, Sweetener, Preservatives and Color.

This product provides natural-source 5-HTP that is peak X-free.

Solgar’s KOF-K certification #K-1250

Non-GMO Gluten, Wheat & Dairy free

Suitable for vegans

Additional Information

5-HTP supports your brain’s production of serotonin. This formulation helps to promote both a positive mood and a state of relaxation.

SOLGB71448 04D

Since 1947

M Halal

Certified Gluten-Free GF

K Parve

Positive mood support Promotes relaxation

Store at room temperature.

Metadata

Product Details

UPC / SKU0 33984 01453 4
DSLD Entry Date2016-10-22
Product TypeBotanical with Nutrients
FormCapsule
BrandSolgar
DSLD ID65483
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.