Glucosamine HCl 1500 mg Plus MSM 1500 mg by Schiff — Ingredients, Evidence & Safety

Product Label

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Label Data

2 Tablet(s) Serving Size

100 Servings

Non-Nutrient/Non-Botanical Product Type

20% Evidence Coverage

Supplement Facts — Evidence Check

Calories

5 {Calories}

Total Carbohydrates

1 Gram(s) (1% DV)

Glucosamine Hydrochloride

1.5 Gram(s)

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1.5mg

MSM

1.5 Gram(s)

📊 Market median: 1000.0mg (2 products)

This product: 1.5mg

Hyaluronic Acid

3.3 mg

📊 Market median: 100.0mg (173 products)

Median 100.0mg This product: 3.3mg

Other Ingredients

Coating Hydroxypropyl Cellulose Silicon Dioxide Magnesium Stearate Boron Glycinate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

DIRECTIONS: Adults take two (2) tablets with a meal OR one (1) tablet twice daily with meals. Recommended limit: Maximum 1 serving per day.

⚠️ Warnings & Precautions

OptiMSM, the MSM in this product, is a registered trademark of Bergstrom Nutrition.

CONTAINS SHELLFISH (SHRIMP AND CRAB)

KEEP OUT OF REACH OF CHILDREN.

If pregnant, breastfeeding, or on prescribed medication, consult your physician before use.

Protected with a tamper evident seal. Do not use if seal under cap is broken or missing.

🧪 Formulation Notes

GUARANTEED: No added sugar (sucrose, fructose, lactose), salt (sodium chloride), yeast, wheat, gluten or milk. No preservatives or artificial flavors.

Glucosamine HCl 1500 mg Plus MSM 1500 mg per 2 tablets

~ High Potency Glucosamine with Hyaluronic Acid & MSM

CONTAINS SHELLFISH (SHRIMP AND CRAB)

Additional Information

HIGH POTENCY - Glucosamine Hydrochloride (HCl) has a high potency of active Glucosamine. Glucosamine HCl is about 83% Glucosamine, while some brands use Glucosamine Sulfate that is only about 65% Glucosamine.

OptiMSM

SURE DISSOLVE

Actual size

Schiff Quality Guarantee

GUARANTEED for purity, freshness and labeled potency.

Since 1936

~ Helps lubricate & protect joints

rb Health ~ Hygiene ~ Home

Store in a cool, dry place with lid tightly closed.

101315 8231641

SCHIFF NUTRITION OVER 75 YEARS OF WELLNESS

Product Details

UPC / SKU 0 20525 11013 8

DSLD Entry Date 2016-05-22

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand Schiff

DSLD ID 59943

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →