TMG Betaine - 1,000 mg

product on market Tablet or Pill NOW 🟢 Safety: 100/100
Brand: NOW
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
33 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

3 Gram(s)
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 3mg

Other Ingredients

Cellulose Stearic Acid Croscarmellose Sodium Magnesium Stearate Vegetarian Coating

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage: Take 1-3 tablets twice daily, preferably with food.

⚠️ Warnings & Precautions

Keep the bottle tightly closed at all times in between usage. Keep the freshness packet in bottle.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

🧪 Formulation Notes

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Additional Information

This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool, dry place after opening.

CODE 0494 V5

TABLET SIZE

Liver Support*

~ Supports Healthy Homocysteine Levels* ~ Promotes Normal Methylation Processes*

Vitamins

Family owned since 1968.

Natural color variation may occur in this product.

Please Recycle.

GMP QUALITY ASSURED

Betaine Anhydrous, or TMG (Trimethylglycine) is known to facilitate methylation processes.* Methylation is a normal biological process that is critical for DNA repair, liver detoxification mechanisms, lipid metabolism, and the production of SAMe.* It is also an important step in the conversion of homocysteine, a damaging amino acid, into a friendlier amino acid, methionine.* Supplementation with TMG has been shown in clinical and non-clinical studies to support healthy homocysteine levels already within normal range.*

Product Details

UPC / SKU 7 33739 00494 9
DSLD Entry Date 2015-07-24
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
Brand NOW
DSLD ID 47884
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
PubMed DOI
View all evidence for Betaine →

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