Synastat Plus

product on market Capsule Sylvan Therapeutics 🟢 Safety: 100/100
Brand: Sylvan Therapeutics
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1200 mg
📊 Market median: 1000.0mg (223 products) 📚 11 studies (Tier A: 0, B: 5)
This product: 1200mg
50 mg
📊 Market median: 100.0mg (283 products) 📚 142 studies (Tier A: 1, B: 64)
This product: 50mg UL 1200mg

Other Ingredients

organic Brown Rice organic Soy Vegetarian Capsule

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (74% of products) Nutrient (7% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Sugar Free

Product Information

📋 Directions for Use

Suggested use: As a dietary supplement for adults, take two (2) capsules twice per day with water at mealtimes or as directed by a licensed healthcare practitioner. Do not exceed four (4) capsules in a 24-hour period.

⚠️ Warnings & Precautions

WARNING: Do not use if you are pregnant, may become pregnant, breastfeeding, or under the age of twenty. Individuals with liver disease or those currently taking statins or other medications should consult with a licensed healthcare practitioner prior to use.

Should not be taken with grapefruit products.

This product contains a chemical known to the State of California to cause birth defects and other reproductive harm.

Do not use if tamper seal is broken or missing.

Keep out of reach of children.

🧪 Formulation Notes

Red Yeast Rice

Vegetarian

NON-GMO

Contains no artificial colors or flavors, corn, lactose, sugar or preservatives.

Additional Information

Sylvan Therapeutics Synastat is produced by Sylvan Bio, Inc., the only U.S. producer of red yeast rice. This product is grown, produced and bottled in the United States. Every batch is rigorously tested for consistency and quality. Synastat is designed to be used by adults to help maintain healthy cholesterol levels, in combination with a healthy lifestyle.

This product was bottled according to the Natural Products Association's Good Manufacturing Practices (GMP).

Grown & Manufactured in the USA

Helps maintain healthy LDL cholesterol levels

Product Details

UPC / SKU 8 13892 00320 8
DSLD Entry Date 2015-07-24
Product Type Other Combinations
Form Capsule
Brand Sylvan Therapeutics
DSLD ID 47184
Data Updated 2026-04-11

Research Evidence

13 Research Sources
53 Avg Quality Score
5 Rct
5 Meta Analysis
2 Clinical Trial
1 Regulatory Source
B Impact of red yeast rice supplementation on lipid profile: a systematic review and meta-analysis of randomized-controlled trials
Meta Analysis Expert review of clinical pharmacology 2023
PubMed DOI
B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Rct Nutrients 2023
PubMed DOI
B Original Research: The Effects of Red Yeast Rice Supplementation on Cholesterol Levels in Adults
Meta Analysis The American journal of nursing 2017
PubMed DOI
B Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia
Rct Nutrients 2022
PubMed DOI
B Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial
Rct Asia Pacific journal of clinical nutrition 2021
PubMed DOI
C Impact of Monacolin K-Containing Supplements on Lipid Profile: A Meta-Analysis of Randomised Controlled Trials
Meta Analysis Endocrinology, diabetes & metabolism 2026
PubMed DOI
C Traditional Chinese lipid-lowering agent red yeast rice results in significant LDL reduction but safety is uncertain - a systematic review and meta-analysis
Meta Analysis Atherosclerosis 2015
PubMed DOI
C Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials
Meta Analysis Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2016
PubMed DOI
C Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: A double blind, placebo controlled randomized trial
Rct BMC complementary and alternative medicine 2015
PubMed DOI
C No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial
Rct Chinese journal of integrative medicine 2017
PubMed DOI
View all evidence for Red Yeast Rice →

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