Waterex

product on market Other (e.g. tea bag) GNC Total Lean Safety: 90/100
90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Vitamin B6, magnesium, and potassium are commonly used to support fluid balance and metabolic function. There is moderate evidence that these nutrients help manage water retention. However, the proprietary blend lacks transparency, and overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Waterex
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Gray Capsule(s)
Serving Size
Botanical
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (1250% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
25 mg (6% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)
Potassium
25 mg (1% DV)
Proprietary Blend
50 mg

Other Ingredients

Cellulose Gelatin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take the contents of one pak daily.

Warnings & Precautions

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

KEEP OUT OF REACH OF CHILDREN.

Additional Information

These premium ingredients help by boosting energy and supporting metabolism.

~Boosts energy, metabolism and reduces calorie intake by 10% ~Clinically studied multivitamin to fuel your active lifestyle ~Exclusive herbal blend designed to regulate water balance ~Enhanced formula includes stress defense nutrients and promotes positive mood support

CLINICALLY RESEARCHED

In a randomized, double-blind, placebo-controlled study of 112 healthy volunteers, subjects taking the GNC vitamin and mineral blend in this product for six weeks experienced statistically significant improvements in markers of B vitamin and antioxidant status, as well as improvements in SF-36 Vitality and Mental Health scores compared to those taking a placebo.

Conforms to USP <2091> for weight Meets USP <2040> disintegration.

GNC QUALITY COMMITMENT For more than 77 years, GNC has been the leader in the development of superior nutritional supplements. Our products are produced using only fresh, high-quality ingredients and are manufactured under the strictest quality controls. GNC GUARANTEE If you are not 100% completely satisfied, return the unused portion of the product with your receipt to a GNC store withing 30 days. Our trained sales staff will either refund your purchase price or, if you prefer, assist you in finding a replacement product to help your LIVE WELL.

CODE 519811 COG

Four separate components work together to boost your metabolism, ignite your energy, help regulate water balance and promote positive mood support.

Metadata

Product Details

DSLD Entry Date2014-08-26
Product TypeBotanical
FormOther (e.g. tea bag)
DSLD ID36333
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.