Brain Power Stack by Host Defense Mushrooms — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label Data

0.5 Teaspoon(s) Serving Size

66 Servings

Botanical with Nutrients Product Type

40% Evidence Coverage

Supplement Facts — Evidence Check

Calories

5 Calorie(s)

Total Carbohydrates

1 Gram(s) (1% DV)

Niacin

50 mg (312% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 50mg UL 35mg

Vitamin B12

500 mcg (20833% DV)

📊 208.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.5mg

Lion's Mane

1.45 Gram(s)

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Organic Gluten Free Dairy Free

Product Information

📋 Directions for Use

Can be mixed into your favorite recipe. Directions: Adults take 1/2 tsp. per day with food.

⚠️ Warnings & Precautions

Caution: Use of this product may cause skin flushing, burning, itching, or rash. Do not take on an empty stomach.

If you have a medical condition, are taking medications, or are pregnant or breastfeeding, consult a healthcare professional before using this product.

Keep out of reach of children.

🧪 Formulation Notes

Powered by mushroom mycelium Brainpower Stack Developed by Paul Stamets for optimal concentration, focus, and memory. Our bioavailable Lion's Mane mushroom mycelium powder is organically grown in the USA.

Vegan

GF Gluten free

Lion's Mane Mushroom Mycelium Powder & B Vitamins

Promotes a mental edge

Non GMO

USDA Organic Certified Organic Washington State Department of Agriculture Organic Program Certified Organic by WSDA

Additional Information

Certified B Corporation

Paul Stamets Paul Stamets Fungi Perfecti, LLC Eco packaging

Vegan

USDA Organic

Certified Organic Washington State Department of Agriculture Organic Program

Product Details

UPC / SKU 6 33422 39777 1

DSLD Entry Date 2025-07-24

Product Type Botanical with Nutrients

Form Powder

Brand Host Defense Mushrooms

DSLD ID 335810

Data Updated 2026-04-11

Research Evidence

241 Research Sources

55 Avg Quality Score

113 Meta Analysis

75 Systematic Review

32 Rct

11 Clinical Trial

3 Other

3 Regulatory Source

1 Cochrane Review

1 Narrative Review

1 Openfda Safety

A Niacin for primary and secondary prevention of cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases

Meta Analysis BMJ (Clinical research ed.) 2013

PubMed DOI

A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients

Meta Analysis BMJ (Clinical research ed.) 2014

PubMed DOI

A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

Meta Analysis Nature medicine 2024

PubMed DOI

A Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Meta Analysis Nature genetics 2010

PubMed DOI

A Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Meta Analysis Nature genetics 2010

PubMed DOI

A Antidepressants for smoking cessation

Meta Analysis The Cochrane database of systematic reviews 2014

PubMed DOI

A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI Cochrane

B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis

Meta Analysis JAMA network open 2019

PubMed DOI

B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

Meta Analysis JAMA 2016

PubMed DOI

View all evidence for Niacin →