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SAM-e & TMG Natural Lemon Flavor

product on market Powder XYMOGEN Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 20% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

S-adenosyl-L-methionine (SAM-e) and betaine anhydrous are utilized to support methylation processes and mood regulation. Research provides moderate evidence for the efficacy of SAM-e in managing depressive symptoms. The combination is designed to maintain homocysteine balance, though overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAM-e & TMG Natural Lemon Flavor
Open Full PDF View on NIH DSLD →
Details

Label Data

2.6 Gram(s)
Serving Size
30
Servings
Other Combinations
Product Type
20%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Carbohydrate
1 Gram(s) (1% DV)
Calcium
75 mg (6% DV)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Xylitol Citric Acid Malic Acid Stearic Acid Silica Lemon Flavor, Natural Turmeric Extract
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Consume the contents of one stick pack daily away from meals, or as directed by your healthcare professional. Preferably pour a small amount of the contents of a stick pack directly into the mouth and allow contents to dissolve. Then repeat process until contents of the entire stick pack have dissolved in the mouth. Alternatively, contents may be added to 2-4 oz of water or preferred liquid; stir and drink within 15 minutes.

Warnings & Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Use special caution in individuals with bipolar disorder. Do not use if stick pack is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation Notes

SAM-e & TMG is a sweet, yet slightly tart lemon-flavored powder. SAM-e (S-adenosyl-L-methionine) and TMG (trimethylglycine) are naturally occurring substances that act as methyl donors during vital biochemical processes in the body. Methylation is essential to normal cell health and function. It can decline with age or chronic alcohol consumption, and it can be limited in some individuals due to their genetic makeup. SAM-e donates methyl groups, which are needed for the synthesis of neurotransmitters, proteins, nucleic acids, and phospholipids. It supports glutathione production, liver health, joint comfort, and a healthy mood. TMG is an especially important methyl donor involved in the metabolism of homocysteine and the formation of SAM-e. TMG ultimately supports cardiovascular and neurological health, as well as normal cell-life regulation. XYMOGEN’s SAM-e & TMG formulation contains a minimum of 70% of the SS isomer of SAM-e, the active form the body can use most readily. This concentration makes SAM-e & TMG cost effective as most SAM-e formulations on the market contain less than 44% active SS isomer.

Formulated to exclude: Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Methyl donors

Additional Information

GMP compliant third-party verified

This packaged is completely recyclable

Storage: Keep closed in a cool, dry place out of reach of children.

30 - 0.09 oz (2.6 g) stick packs Scan this code to learn more!

ePV (ePedigree Verification)

Clean seas Turn the tide on plastic #CleanSeas XYMOGEN is committed to reducing the amount of plastics used throughout our business, particularly in the packaging of our products. With our participation in the United Nations Environment Programme Clean Seas initiative, we strive to positively decrease our environmental footprint, providing results that can ultimately: - Help free the ocean of litter, making it safer for millions of marine animals. - Reduce the use of non-renewable resources. - Keep wild-caught seafood healthy and safe to eat. - Protect maritime economies such as organic fishing, tourism, and recreation.

Metadata

Product Details

UPC / SKU8 71149 00204 6
DSLD Entry Date2025-09-25
Product TypeOther Combinations
FormPowder
BrandXYMOGEN
DSLD ID335565
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.