🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 20% of ingredients have research evidence
B Label Compliance Grade

Product Label

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Label Data

2.6 Gram(s) Serving Size
30 Servings
Other Combinations Product Type
20% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Carbohydrate
1 Gram(s) (1% DV)
Calcium
75 mg (6% DV)
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 600mg
📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 400mg

Other Ingredients

Xylitol Citric Acid Malic Acid Stearic Acid Silica Lemon Flavor, Natural Turmeric Extract

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) No Allergies Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Consume the contents of one stick pack daily away from meals, or as directed by your healthcare professional. Preferably pour a small amount of the contents of a stick pack directly into the mouth and allow contents to dissolve. Then repeat process until contents of the entire stick pack have dissolved in the mouth. Alternatively, contents may be added to 2-4 oz of water or preferred liquid; stir and drink within 15 minutes.

⚠️ Warnings & Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Use special caution in individuals with bipolar disorder. Do not use if stick pack is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

🧪 Formulation Notes

SAM-e & TMG is a sweet, yet slightly tart lemon-flavored powder. SAM-e (S-adenosyl-L-methionine) and TMG (trimethylglycine) are naturally occurring substances that act as methyl donors during vital biochemical processes in the body. Methylation is essential to normal cell health and function. It can decline with age or chronic alcohol consumption, and it can be limited in some individuals due to their genetic makeup. SAM-e donates methyl groups, which are needed for the synthesis of neurotransmitters, proteins, nucleic acids, and phospholipids. It supports glutathione production, liver health, joint comfort, and a healthy mood. TMG is an especially important methyl donor involved in the metabolism of homocysteine and the formation of SAM-e. TMG ultimately supports cardiovascular and neurological health, as well as normal cell-life regulation. XYMOGEN’s SAM-e & TMG formulation contains a minimum of 70% of the SS isomer of SAM-e, the active form the body can use most readily. This concentration makes SAM-e & TMG cost effective as most SAM-e formulations on the market contain less than 44% active SS isomer.

Formulated to exclude: Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Methyl donors

Additional Information

GMP compliant third-party verified

This packaged is completely recyclable

Storage: Keep closed in a cool, dry place out of reach of children.

30 - 0.09 oz (2.6 g) stick packs Scan this code to learn more!

ePV (ePedigree Verification)

Clean seas Turn the tide on plastic #CleanSeas XYMOGEN is committed to reducing the amount of plastics used throughout our business, particularly in the packaging of our products. With our participation in the United Nations Environment Programme Clean Seas initiative, we strive to positively decrease our environmental footprint, providing results that can ultimately: - Help free the ocean of litter, making it safer for millions of marine animals. - Reduce the use of non-renewable resources. - Keep wild-caught seafood healthy and safe to eat. - Protect maritime economies such as organic fishing, tourism, and recreation.

Product Details

UPC / SKU 8 71149 00204 6
DSLD Entry Date 2025-09-25
Product Type Other Combinations
Form Powder
Brand XYMOGEN
DSLD ID 335565
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
View all evidence for Same →

Compare Similar Products

View all Same products →