SAM-e 400 mg by SuperSmart — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

30 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

S-Adenosyl Methionine

800 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 800mg

Other Ingredients

Microcrystalline Cellulose Magnesium Hydroxide Stearic Acid Calcium Chloride Anhydrous Magnesium Stearate Colloidal Silica Anhydrous Calcium Oxide Talc Shellac Arginine Glycerol Silicon Dioxide Sodium Alginate

Label Claims — Verification

❓ All Other

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: Take one or two tablets a day, on an empty stomach.

⚠️ Warnings & Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of childrens' reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem. Warning: Anyone taking prescription anti-depressants should consult their doctor before using this product. Those being treated for Parkinson's disease or manic depression (bi-polar depression) should not take SAM-e. This product is a nutritional supplement, it is not a medicine.

🧪 Formulation Notes

Each gastro-resistant tablet provides 400 mg of elemental S-Adenosyl Methionine derived from 800 mg SAM-e tosylate disulfate.

Additional Information

Store away from direct light, heat and humidity.

Product Details

DSLD Entry Date 2025-06-25

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand SuperSmart

DSLD ID 332492

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis