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Methyl B12

product on market Tablet or Pill MegaFood Safety: 90/100
90/100

This product looks safe

  • Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)
  • 75% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B12, folate, and B6 are supported by strong evidence for maintaining neurological function and supporting red blood cell formation. These nutrients play critical roles in homocysteine regulation and energy metabolism. Evidence coverage for this specific formulation is limited, though the individual components have well-documented safety profiles.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Methyl B12
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
90
Servings
Botanical with Nutrients
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

8 mg (471% DV)
6.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
340 mcg DFE (85% DV)
Exceeds UL by 340.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
500 mcg (20833% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
Food Blend
242 mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Silicon Dioxide Rice Protein Hypromellose Autolyzed Yeast Extract
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults take 1 tablet daily with a beverage. May be taken any time of day, even on an empty stomach.

Warnings & Precautions

Keep out of reach of children.

Formulation Notes

Made without milk, eggs, peanuts, tree nuts, soy, wheat, fish, shellfish and sesame.

Tested for 125+ Pesticides Herbicides Glyphosate Residue Free detoxproject.org Made without 9 Food Allergens Gluten Free

Certified Vegan Vegan.org

OK (Kosher)

Supports cellular energy production with the active form of B12 Methyl B12 Plus food blend

Non GMO Project Verified nongmoproject.org

MegaFood Methyl B12 contains the active form of vitamin B6 and methylated (active) forms of folate and B12 to help support heart and blood health and to maintain healthy levels of homocysteine, an amino acid found in the blood. This product is made with food-paired vitamins.

Satisfaction guaranteed or your money back.

Additional Information

Learn about our seals: megafood.com/standards

Tested for 125+ Pesticides Herbicides Glyphosate Residue Free detoxproject.org Certified Vegan Vegan.org Certified B Corporation OK (Kosher)

Non GMO Project Verified nongmoproject.org

We believe that the most nutritious food comes from healthy soil. Our goal is to partner with farmers who share our commitment to regenerative agriculture, working to nourish the soil for quality ingredients that make for premium supplements.

Store tightly sealed in a cool place and avoid exposure to moisture. Once open, consume within three months.

Metadata

Product Details

UPC / SKU0 51494 10333 3
DSLD Entry Date2025-03-25
Product TypeBotanical with Nutrients
FormTablet or Pill
BrandMegaFood
DSLD ID327570
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.